Tolerogenic IDO(+) Dendritic Cells Are Induced by PD-1-Expressing Mast Cells

Frontiers in Immunology
Cecilia Pessoa RodriguesJosé Alexandre M Barbuto

Abstract

Mast cells (MCs) are tissue resident cells, rich in inflammatory mediators, involved in allergic reactions, and with an increasingly recognized role in immunomodulation. Dendritic cells (DCs), on the other hand, are central to the determination of immune response patterns, being highly efficient antigen-presenting cells that respond promptly to changes in their microenvironment. Here, we show that direct cell contact between immature monocyte-derived DCs (iDCs) and MC bends DCs toward tolerance induction. DCs that had direct contact with MC (MC-iDC) decreased HLA-DR but increased PD-L1 expression and stimulated regulatory T lymphocytes, which expresses FoxP3(+), secrete TGF-β and IL-10, and suppress the proliferation of mitogen-stimulated naïve T lymphocytes. Furthermore, MC-iDC expressed higher levels of indoleamine-2,3-deoxigenase (IDO), a phenomenon that was blocked by treatment of MC with anti-PD-1 or by the treatment of DCs with anti-PD-L1 or anti-PD-L2, but not by blocking of H1 and H2 histamine receptors on DCs. Contact with MC also increased phosphorylated STAT-3 levels in iDCs. When a STAT-3 inhibitor, JSI-124, was added to the DCs before contact with MC, the MC-iDC recovered their ability to induce allogeneic T cell p...Continue Reading

References

Apr 1, 1998·Nature·J Banchereau, R M Steinman
May 9, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·G CaronP Jeannin
Sep 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·G CaronP Jeannin
May 4, 2004·Nature Reviews. Immunology·Lieping Chen
Jul 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jens M ChemnitzJames L Riley
Jan 22, 2005·Nature Immunology·Stephen J GalliMindy Tsai
Mar 18, 2005·Annual Review of Immunology·Stephen J GalliMindy Tsai
Aug 2, 2005·Nature Reviews. Immunology·Gwendalyn J RandolphMelody A Swartz
Feb 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Susumu NakaeStephen J Galli
May 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Francesca FallarinoPaolo Puccetti
Aug 22, 2006·Nature·Li-Fan LuRandolph J Noelle
Sep 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alessandra MazzoniDavid M Segal
Dec 29, 2006·Annals of the New York Academy of Sciences·Theoharis C Theoharides, Dimitrios Kalogeromitros
Apr 3, 2007·Trends in Immunology·Martin Metz, Marcus Maurer
May 10, 2007·Nature Protocols·Hirohisa SaitoYoshimichi Okayama
May 15, 2007·Immunological Reviews·Jean-Pierre Kinet
May 15, 2007·Immunological Reviews·Blayne Amir Sayed, Melissa A Brown
Jul 25, 2007·Journal of Gastroenterology and Hepatology·Maya Gulubova, Tatyana Vlaykova
Nov 1, 2007·European Journal of Immunology·Ralph M Steinman
May 17, 2008·Nature Reviews. Immunology·Stephen J GalliMindy Tsai
Oct 4, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria L BelladonnaPaolo Puccetti
Dec 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ciriana OrabonaPaolo Puccetti
Aug 18, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·V C de VriesR J Noelle
Mar 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Nichole R BlatnerKhashayarsha Khazaie
Feb 3, 2011·Methods in Molecular Biology·Lauren W Collison, Dario A A Vignali
Apr 15, 2011·European Journal of Immunology·Anne DudeckMarcus Maurer
Jul 9, 2011·The Journal of Clinical Investigation·Mang YuStephen J Galli
Aug 2, 2011·Nature Immunology·Maria T PallottaUrsula Grohmann
Nov 1, 2011·Immunity·Victor C de VriesRandolph J Noelle
May 29, 2012·Journal of Leukocyte Biology·Rodrigo Nalio RamosJosé Alexandre M Barbuto
Jun 14, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Grazia AndolfiMaria-Grazia Roncarolo
Jul 31, 2012·International Journal of Inflammation·Ross N England, Michael V Autieri
Aug 7, 2012·European Journal of Immunology·Francesca FallarinoPaolo Puccetti
Sep 14, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joakim S DahlinJenny Hallgren
Dec 26, 2012·Allergology International : Official Journal of the Japanese Society of Allergology·Tatsuki R KataokaHironori Haga
Feb 7, 2013·Molecular Cancer Research : MCR·Braden C McFarlandEtty N Benveniste
Apr 23, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ashley L St John, Soman N Abraham
Jun 14, 2013·Clinical & Developmental Immunology·Rodrigo Nalio RamosJosé Alexandre M Barbuto
Apr 12, 2014·Scientific Reports·Zhi-Qiang LiuPing-Chang Yang
Apr 30, 2014·Cancer Immunology Research·Thomas MarichalStephen J Galli
Jul 27, 2014·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Elaine Zayas Marcelino da SilvaConstance Oliver

❮ Previous
Next ❯

Citations

Jul 1, 2017·International Journal of Tryptophan Research : IJTR·Hector Rodriguez Cetina BieferAbdallah Elkhal
Sep 19, 2017·Allergy·E Jensen-JarolimS N Karagiannis
Aug 3, 2018·Journal of Hematology & Oncology·Ming LiuYong Li
Apr 15, 2020·Scientific Reports·Anne-Claire DesboisDavid Saadoun
Sep 14, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tom Groot KormelinkMarca H M Wauben
Apr 13, 2018·Frontiers in Oncology·Judith A SeidelKenji Kabashima
Nov 27, 2016·Seminars in Immunopathology·K Sanjana P Devi, Niroshana Anandasabapathy
Aug 5, 2017·Frontiers in Medicine·Mélanie VaesOlivier Hermine
Oct 20, 2020·Frontiers in Immunology·Annabel MeiresonLieve Brochez
May 14, 2021·Research in Veterinary Science·Akira MatsudaHiroshi Matsuda

❮ Previous
Next ❯

Methods Mentioned

BETA
leukapheresis
flow cytometry
PMA
PCR

Software Mentioned

GraphPad Prism
MXPro3000
FlowJo

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.