Toll-Interacting Protein in Resolving and Non-Resolving Inflammation

Frontiers in Immunology
Elizabeth J A Kowalski, Liwu Li

Abstract

Innate leukocytes manifest dynamic and distinct inflammatory responses upon challenges with rising dosages of pathogen-associated molecular pattern molecules such as lipopolysaccharide (LPS). To differentiate signal strengths, innate leukocytes may utilize distinct intracellular signaling circuitries modulated by adaptor molecules. Toll-interacting protein (Tollip) is one of the critical adaptor molecules potentially playing key roles in modulating the dynamic adaptation of innate leukocytes to varying dosages of external stimulants. While Tollip may serve as a negative regulator of nuclear factor κ of activated B cells signaling pathway in cells challenged with higher dosages of LPS, it acts as a positive regulator for low-grade chronic inflammation in leukocytes programmed by subclinical low-dosages of LPS. This review aims to discuss recent progress in our understanding of complex innate leukocyte dynamics and its relevance in the pathogenesis of resolving versus non-resolving chronic inflammatory diseases.

References

Nov 1, 1994·Clinical and Diagnostic Laboratory Immunology·T GotoI Mattsby-Baltzer
Dec 10, 1999·Journal of the American College of Cardiology·C J WiedermannJ Willeit
Mar 11, 2000·Molecular Biology of the Cell·A MayerA Haas
Mar 17, 2000·Immunological Reviews·R Medzhitov, C Janeway
Jul 27, 2000·Annals of the New York Academy of Sciences·C FranceschiG De Benedictis
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K J MooreM W Freeman
Jul 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·S BauerG B Lipford
Dec 26, 2001·The Journal of Biological Chemistry·Guolong Zhang, Sankar Ghosh
Mar 16, 2002·Nature Immunology·Vladimir ToshchakovStefanie N Vogel
Jun 11, 2002·Nature Immunology·Yoshinori NagaiKensuke Miyake
Jun 7, 2003·Science·Gregory M Barton, Ruslan Medzhitov
Oct 18, 2003·The Journal of Biological Chemistry·Megumi YamakamiHideyoshi Yokosawa
Feb 7, 2004·The Journal of Biological Chemistry·Kristen R TaylorRichard L Gallo
Feb 21, 2004·Science·Sandra S DieboldCaetano Reis e Sousa
Mar 23, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jennifer M LundRichard A Flavell
May 14, 2004·Molecular Immunology·Tao LiLiwu Li
Jun 24, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M MaachiJ-P Bastard
Jul 2, 2004·Nature Reviews. Immunology·Shizuo Akira, Kiyoshi Takeda
Dec 14, 2004·Journal of Endotoxin Research·Evelyn A Kurt-JonesRobert W Finberg
Jan 5, 2005·The Journal of Experimental Medicine·Cevayir CobanShizuo Akira
Jan 18, 2006·Biochemical and Biophysical Research Communications·Yohei KatohKazuhisa Nakayama
Jan 24, 2006·Molecular and Cellular Biology·Arnaud DidierlaurentKimberly Burns
Feb 25, 2006·Cell·Shizuo AkiraOsamu Takeuchi
Dec 6, 2006·Annals of the New York Academy of Sciences·Marc S LamphierEicke Latz
Dec 28, 2006·Journal of Biochemistry·Taro Kawai, Shizuo Akira
Feb 6, 2007·Seminars in Immunology·Taro Kawai, Shizuo Akira
Feb 8, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Cheuk-Chun SzetoPhilip Kam-Tao Li
Sep 2, 2008·Blood·Bruce A Beutler
Mar 18, 2009·Journal of Leukocyte Biology·Michelle H W LairdStefanie N Vogel
Jul 4, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Radhakrishna Rao
Mar 23, 2010·The Journal of Nutritional Biochemistry·Fabienne LaugeretteMarie-Caroline Michalski
Nov 26, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Edward A MedinaMichael T Berton
Dec 24, 2010·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Hiroyuki TerawakiTatsuo Hosoya
Mar 2, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Urmila MaitraLiwu Li
Apr 8, 2011·American Journal of Respiratory and Critical Care Medicine·Ganesh RaghuUNKNOWN ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis
Sep 21, 2011·Microbes and Infection·Daniel G S Capelluto
Jun 19, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Urmila MaitraLiwu Li

❮ Previous
Next ❯

Citations

Jun 17, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Naveen ParmarSusanta Kar
Sep 27, 2018·Journal of Cellular and Molecular Medicine·Michael SchuligaDarryl A Knight
Jul 3, 2019·NPJ Genomic Medicine·Salla KeskitaloMarkku Varjosalo
Nov 1, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Xiaoyun LiYingze Zhang

❮ Previous
Next ❯

Software Mentioned

Tollip

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.