Toll-Like Receptor 2-Mediated Glial Cell Activation in a Mouse Model of Cuprizone-Induced Demyelination

Molecular Neurobiology
Stefan EsserLars-Ove Brandenburg

Abstract

Multiple sclerosis (MS) is a chronic degenerative disease of the central nervous system that is characterized by myelin abnormalities, oligodendrocyte pathology, and concomitant glia activation. The factors triggering gliosis and demyelination are currently not well characterized. New findings suggest an important role of the innate immune response in the initiation and progression of active demyelinating lesions. Especially during progressive disease, aberrant glia activation rather than the invasion of peripheral immune cells is accountable for progressive neuronal injury. The innate immune response can be induced by pathogen-associated or danger-associated molecular patterns, which are identified by pattern recognition receptors (PRRs), including the Toll-like receptors (TLRs). In this study, we used the cuprizone model in mice to investigate the expression of TLR2 during the course of cuprizone-induced demyelination. In addition, we used TLR2-deficient mice to analyze the functional role of TLR2 activation during cuprizone-induced demyelination and reactive gliosis. We show a significantly increased expression of TLR2 in the corpus callosum and hippocampus of cuprizone-intoxicated mice. The absence of receptor signaling in ...Continue Reading

References

Sep 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Norbert ReilingStefan Ehlers
Mar 30, 2004·Annals of Neurology·Michael H Barnett, John W Prineas
Aug 11, 2006·Journal of Neurochemistry·Gregory W KonatIan Marriott
May 10, 2007·Current Neurology and Neuroscience Reports·Hans Lassmann
Mar 20, 2008·The American Journal of Pathology·Thomas SkripuletzMartin Stangel
Apr 1, 2008·Journal of Molecular Neuroscience : MN·Markus KippCordian Beyer
Jul 23, 2008·Journal of Leukocyte Biology·Asa AnderssonRobert A Harris
Sep 23, 2008·Journal of Neuroimmunology·Meenaxi M HiremathGlenn K Matsushima
May 7, 2009·Current Opinion in Neurology·Paul van der Valk, Sandra Amor
Sep 4, 2009·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Monica M Mariani, Tammy Kielian
Sep 19, 2009·Acta Neuropathologica·Markus KippCordian Beyer
Jun 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·J A SloaneT Vartanian
Aug 5, 2010·Clinical and Experimental Immunology·J M FletcherK H G Mills
Apr 22, 2011·Journal of Neuroendocrinology·Tim ClarnerMarkus Kipp
Apr 3, 2012·The Journal of Clinical Investigation·Richard M Ransohoff, Melissa A Brown
May 16, 2012·CNS & Neurological Disorders Drug Targets·Markus KippSandra Amor
May 16, 2012·CNS & Neurological Disorders Drug Targets·Baukje J van der StarSandra Amor
Jun 26, 2012·Immunological Reviews·Lior MayoHoward L Weiner
Nov 13, 2012·Journal of Neuroimmunology·Lars-Ove BrandenburgSimone C Tauber
Dec 26, 2012·Brain : a Journal of Neurology·Thomas SkripuletzMartin Stangel
Feb 6, 2013·The Journal of Cell Biology·Yasuhisa SakamotoSandrine Etienne-Manneville
May 15, 2013·Journal of Molecular Neuroscience : MN·Adib ZendedelMarkus Kipp
Nov 1, 2013·Clinical & Developmental Immunology·Norma Y Hernández-PedroJulio Sotelo
Feb 11, 2014·Handbook of Clinical Neurology·Alexandra Kutzelnigg, Hans Lassmann
Mar 1, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tim ClarnerMarkus Kipp
Jun 13, 2015·Journal of Molecular Neuroscience : MN·Johannes GoldbergMarkus Kipp
Jun 24, 2015·Immunologic Research·Zohara SternbergDavid Hojnacki
Sep 14, 2015·Molecular Neurobiology·René Große-VeldmannMarkus Kipp
Oct 16, 2015·Oncotarget·Md Jakir HossainBruno Gran
Jan 29, 2016·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Miriam ScheldMarkus Kipp
Jun 18, 2016·Frontiers in Physiology·Alison BarryEric J Downer
Aug 6, 2016·Journal of Molecular Neuroscience : MN·Nina WagenknechtMarkus Kipp
Oct 12, 2016·Journal of Neuroimmunology·Martin BöhlandLars-Ove Brandenburg
Oct 30, 2016·Brain Pathology·Markus KippSandra Amor
Feb 27, 2017·Journal of Molecular Neuroscience : MN·Tanja HochstrasserMarkus Kipp
May 4, 2017·Journal of Molecular Neuroscience : MN·Kai BihlerLars-Ove Brandenburg
Jun 16, 2017·Molecular Neurobiology·Birte BeckerMarkus Kipp

Citations

Sep 26, 2020·Frontiers in Cellular Neuroscience·Melanie J PlastiniRoberta Brambilla
Jul 29, 2019·Journal of Neuroinflammation·Nicholas J WaskoRobert B Clark
Nov 30, 2019·Frontiers in Immunology·M Elizabeth DeerhakeMari L Shinohara
Oct 4, 2020·Science Advances·Seung-Wan YooNorman J Haughey
Oct 31, 2020·Journal of Neuroinflammation·Marvin RügerLars-Ove Brandenburg
Oct 17, 2020·The International Journal of Neuroscience·Eliska JankovskaJiri Petrak

Methods Mentioned

BETA
fluorescence microscopy

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