Toll-like receptor 3 ligand polyinosinic:polycytidylic acid promotes wound healing in human and murine skin

The Journal of Investigative Dermatology
Qing LinShao Bo Su

Abstract

Toll-like receptors (TLRs) are pattern-recognition receptors and have a critical role in both innate and adaptive responses to tissue injury. Our previous study showed that wound healing was impaired in TLR3-deficient mice. In this study, we investigated the capacity of the TLR3 agonist polyriboinosinic-polyribocytidylic acid (poly(I:C)) to promote the healing of skin wounds in humans and mice. We found that topical application with poly(I:C) accelerated the closure of wounds in patients with laser plastic surgery. In a mouse model, topical application of poly(I:C) markedly enhanced re-epithelialization, granulation, and neovascularization required for wound closure. Further studies revealed that poly(I:C) treatment resulted in enhanced recruitment of neutrophils and macrophages in association with upregulation of a chemokine, macrophage inflammatory protein-2 (MIP-2/CXCL2), in the wounds. The effect of poly(I:C) was abolished in TLR3-deficient mice or by treatment with MIP-2/CXCL2-neutralizing antibodies. These results suggest a potential therapeutic value of the TLR3 activator poly(I:C) for wound healing.

References

Feb 1, 1992·Journal of Cellular Physiology·D BhartiyaR K Maheshwari
Jun 1, 1991·The British Journal of Dermatology·I A McKay, I M Leigh
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D DanonG S Roth
Sep 2, 1999·The New England Journal of Medicine·A J Singer, R A Clark
Aug 22, 2000·The Journal of Investigative Dermatology·R M DevalarajaA Richmond
Apr 27, 2002·Science·Julie JamesonWendy L Havran
Jun 28, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ryoichi MoriNaofumi Mukaida
Jan 20, 2004·The Journal of Biological Chemistry·Katalin KarikóDrew Weissman
Aug 10, 2005·Biochemical and Biophysical Research Communications·Mikiko TohyamaKoji Hashimoto
Aug 17, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S MatsukuraM Adachi
Feb 15, 2007·The Journal of Investigative Dermatology·Sabine A EmingJeffrey M Davidson
Feb 27, 2007·The American Journal of Pathology·Machteld J van AmerongenMarja J A van Luyn
Feb 12, 2008·Advanced Drug Delivery Reviews·Misako Matsumoto, Tsukasa Seya
Oct 8, 2008·The Journal of Experimental Medicine·Karen A CavassaniSteven L Kunkel
Dec 25, 2008·Annual Review of Immunology·Fernando O MartinezSiamon Gordon
Nov 12, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Chandan K SenMichael T Longaker
Jan 1, 2010·The American Journal of Pathology·Josephine L MartinSabita Roy
Jul 14, 2010·The British Journal of Surgery·C SchürmannS Frank
Oct 16, 2010·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Takashi SatoDennis M Klinman
Mar 5, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Qing LinShao Bo Su
May 24, 2011·International Immunopharmacology·Qing LinShao Bo Su

❮ Previous
Next ❯

Citations

Apr 16, 2013·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Alexey V KostarnoyAlexandr L Gintsburg
Mar 28, 2013·PloS One·Michael MildnerHendrik Jan Ankersmit
Jul 18, 2014·Advances in Wound Care·Irena PastarMarjana Tomic-Canic
Feb 9, 2016·Laboratory Investigation; a Journal of Technical Methods and Pathology·Rachel CromptonMatthew J Hardman
May 3, 2014·The Journal of Investigative Dermatology·Andrew W Borkowski, Richard L Gallo
Aug 26, 2015·Immunology and Cell Biology·Divya RamnathMatthew J Sweet
Aug 12, 2014·The International Journal of Biochemistry & Cell Biology·Daniel J KotaScott D Olson
Jul 2, 2016·European Journal of Pharmacology·Theodoros KarampitsakosArgyris Tzouvelekis
Dec 12, 2012·Biochimica Et Biophysica Acta·Peter Huebener, Robert F Schwabe
Apr 3, 2014·Scientific Reports·Daniel J KotaScott D Olson
Sep 27, 2018·Regenerative Medicine·Lin GongYuan-Hong Li
Aug 16, 2017·International Journal of Inflammation·Mariana Barreto SerraMarilene Oliveira da Rocha Borges
Oct 25, 2017·Advances in Wound Care·Lin Chen, Luisa A DiPietro
Aug 19, 2016·Science China. Life Sciences·Hu LeiYuping Lai
Apr 26, 2017·BMC Immunology·Kazuhide TakadaSatoshi Hayakawa
Jun 18, 2016·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Robert K DeLong, Chandler B Curtis
Dec 12, 2019·Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery·Eliane TagliariLúcia de Noronha
Dec 10, 2019·Journal of Immunology Research·Lixiang SunLing-Juan Zhang
Dec 30, 2020·International Journal of Molecular Sciences·Saaya Koike, Kenshi Yamasaki
Apr 3, 2021·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Ryan J DebuqueJames W Godwin
May 19, 2021·BMC Pulmonary Medicine·Gemma LauraYouming Zhang
Oct 9, 2021·Journal of Cellular and Molecular Medicine·Eric WierLuis A Garza

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
Qing LinShao Bo Su
Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Xiaomin LinShao Bo Su
Journal of Burn Care & Research : Official Publication of the American Burn Association
Haifeng ZhuFerid Murad
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Lars HeggelundStig S Frøland
© 2021 Meta ULC. All rights reserved