Toll-like receptor 4 contributes to colitis development but not to host defense during Citrobacter rodentium infection in mice.

Infection and Immunity
Mohammed A KhanBruce A Vallance

Abstract

Enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli (EHEC) are noninvasive bacterial pathogens that infect their hosts' intestinal epithelium, causing severe diarrheal disease. These infections also cause intestinal inflammation, although the mechanisms underlying the inflammatory response, as well as its potential role in host defense, are unclear. Since these bacteria are gram-negative, Toll-like receptor 4 (TLR4), the innate receptor for bacterial lipopolysaccharide may contribute to the host response; however, the role of TLR4 in the gastrointestinal tract is poorly understood, and its impact has yet to be tested against this family of enteric bacterial pathogens. Since EPEC and EHEC are human specific, we infected mice with Citrobacter rodentium, a mouse-adapted attaching and effacing (A/E) bacterium that infects colonic epithelial cells, causing colitis and epithelial hyperplasia, using a similar array of virulence proteins as EPEC and EHEC. We demonstrated that C. rodentium activates TLR4 and rapidly induced NF-kappaB nuclear translocation in host cells in a partially TLR4-dependent manner. Infection of TLR4-deficient mice revealed that TLR4-dependent responses mediate much of the inflammation and tiss...Continue Reading

References

May 1, 1977·Journal of Gerontology·G L ColemanA M Jonas
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J PuginP S Tobias
Oct 1, 1994·The Journal of Experimental Medicine·O J PerdomoP J Sansonetti
Mar 1, 1997·Trends in Microbiology·M S DonnenbergB B Finlay
Jan 1, 1997·Methods in Enzymology·T J StandifordR M Strieter
Feb 11, 1998·Clinical Microbiology Reviews·J P Nataro, J B Kaper
Jul 7, 1998·The Journal of Experimental Medicine·A G Farr, A Rudensky
Nov 17, 1998·The Journal of Experimental Medicine·A AbeB Brett Finlay
Feb 13, 1999·Molecular Microbiology·G FrankelS Knutton
Mar 6, 1999·Current Opinion in Microbiology·J B Kaper
Mar 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S AkashiK Miyake
Jul 6, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·D J PhilpottP J Sansonetti
Aug 2, 2000·Proceedings of the National Academy of Sciences of the United States of America·B A Vallance, B B Finlay
Feb 15, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·P J Sansonetti
Mar 10, 2001·The Journal of Clinical Investigation·M S Donnenberg, T S Whittam
May 4, 2001·Microbes and Infection·S A Luperchio, D B Schauer
Feb 2, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cameron P SimmonsThomas T MacDonald
Jun 11, 2002·Gastroenterology·M HausmannG Rogler
Oct 31, 2002·Research in Microbiology·Simon ClareGordon Dougan
Mar 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Joel D SchillingScott J Hultgren
May 23, 2003·Infection and Immunity·Bruce A VallanceB Brett Finlay
Jul 10, 2003·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Christine Daly, Barrett J Rollins
Dec 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lynn Bry, Michael B Brenner
Jan 31, 2004·Seminars in Immunology·Kensuke Miyake
Feb 21, 2004·The Journal of Infectious Diseases·Paul B MannEric T Harvill
Feb 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·Wanyin DengB Brett Finlay
May 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrés Vazquez-TorresFerric C Fang

❮ Previous
Next ❯

Citations

Aug 31, 2010·Inflammatory Bowel Diseases·Elke Cario
Apr 12, 2008·Purinergic Signalling·John K CraneTonniele M Naeher
Dec 6, 2011·Current Infectious Disease Reports·John SotolongoMasayuki Fukata
May 18, 2011·Biological Trace Element Research·Allen D SmithSebastian Botero
Oct 31, 2013·Seminars in Immunology·David PrescottDana J Philpott
Sep 30, 2010·Proceedings of the National Academy of Sciences of the United States of America·Leigh A KnodlerOlivia Steele-Mortimer
Aug 17, 2010·The Journal of Biological Chemistry·Parthasarathy ChandrakesanShahid Umar
Jul 16, 2008·The Journal of Biological Chemistry·Prasad RallabhandiStefanie N Vogel
Aug 4, 2010·The Journal of Experimental Medicine·Mark Asquith, Fiona Powrie
May 2, 2007·Infection and Immunity·Diana BorenshteinDavid B Schauer
Jan 15, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Chhinder SodhiDavid J Hackam
Apr 11, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ryan UngaroMaria T Abreu
Aug 6, 2008·Genome Biology·Diana BorenshteinDavid B Schauer
Nov 3, 2011·PloS One·Benjamin P WillingB Brett Finlay
Mar 1, 2012·PloS One·Guilhem RichardSalomon Amar
Dec 31, 2009·PLoS Pathogens·Xiaofei GaoPhilip R Hardwidge
Mar 13, 2014·Microbes and Infection·Leigh Ann Feuerbacher, Philip R Hardwidge
Dec 21, 2013·Current Colorectal Cancer Reports·Shahid Umar
Feb 24, 2015·Journal of Immunological Methods·Ekaterina P KorolevaAlexei V Tumanov
Feb 24, 2016·Nature Reviews. Immunology·Araceli Perez-LopezManuela Raffatellu
Dec 6, 2011·Seminars in Immunology·Bartlomiej Swiatczak, Maria Rescigno

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.