Toll-Like Receptor 4 Deficiency Impairs Motor Coordination

Frontiers in Neuroscience
Jian-Wei ZhuRu-Xiang Xu

Abstract

The cerebellum plays an essential role in balance and motor coordination. Purkinje cells (PCs) are the sole output neurons of the cerebellar cortex and are critical for the execution of its functions, including motor coordination. Toll-like receptor (TLR) 4 is involved in the innate immune response and is abundantly expressed in the central nervous system; however, little is known about its role in cerebellum-related motor functions. To address this question, we evaluated motor behavior in TLR4 deficient mice. We found that TLR4(-∕-) mice showed impaired motor coordination. Morphological analyses revealed that TLR4 deficiency was associated with a reduction in the thickness of the molecular layer of the cerebellum. TLR4 was highly expressed in PCs but not in Bergmann glia or cerebellar granule cells; however, loss of TLR4 decreased the number of PCs. These findings suggest a novel role for TLR4 in cerebellum-related motor coordination through maintenance of the PC population.

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Citations

Sep 7, 2016·Behavioural Brain Research·Nan-Qu HuangFeng Jin
Feb 19, 2020·ELife·Guiyi LiAlicia Hidalgo
Nov 15, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Romina VuonoJanelle Drouin-Ouellet
Feb 7, 2020·Science Translational Medicine·Na ZhaoGuojun Bu
Apr 27, 2018·Development·Niki AnthoneyAlicia Hidalgo
Oct 2, 2020·Brain, Behavior, and Immunity·Patricia SchroederSeija Lehnardt
Jul 3, 2021·International Journal of Molecular Sciences·Chand Basha DavuljigariGaku Ichihara
Aug 24, 2021·Frontiers in Aging Neuroscience·Jian-Wei ZhuRu-Xiang Xu

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Methods Mentioned

BETA
PCR
electrophoresis
confocal microscopy

Software Mentioned

SPSS
ImageJ

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