PMID: 22333167Feb 16, 2012Paper

Toll-like receptor 4 deposition and its significance in hepatitis B virus associated nephropathy

Zhonghua nei ke za zhi
Nan ZhuLi-Jie Gu

Abstract

To investigate the expression and distribution of Toll-like receptor 4 (TLR4) in renal tissue of HBV associated nephropathy (HBV-GN) and its role in the pathogenesis and clinical manifestations of HBV-GN. Renal tissues were sampled from 48 HBV-GN patients confirmed by renal biopsy and 154 non-HBV-GN patients. The distribution of TLR4 in renal tissue and the relationship between the distribution of TLR4 and HBsAg were detected by immunohistochemistry. Integrating case record, correlations between the expression of TLR4 with clinical parameters including pathology, glomeruli, kidney tubules lesions, renal interstitial inflammatory infiltration and blood serum HBV were analyzed. TLR4 mainly distributed in the renal tubular epithelial cells and interstitial areas as brownish red and granular, which was in consistent with HBsAg distribution. The TLR4 positive rate and score in HBV-GN group were higher than those in non-HBV-GN group (P < 0.05). TLR4 positive score was slightly higher in mesangial proliferative glomerulonephritis group and focal segmental glomerulosclerosis group, which had no significant difference (P > 0.05). Kidney tubules lesions were strongly associated with TLR4 expression (r = 0.748, P < 0.001) which increased ...Continue Reading

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