Toll-like receptor 4 mediates chronic restraint stress-induced immune suppression

Journal of Neuroimmunology
Yi ZhangDeling Yin

Abstract

Stress, either physical or psychological, can have a dramatic impact on the immune system. Little progress, however, has been made in understanding stress-induced immune suppression. We report here that mice subjected to chronic 12-hour daily physical restraint for two days significantly increased the expression of Toll-like receptor 4 (TLR4). Interestingly, TLR4-deficient mice are resistant to stress-induced lymphocyte reduction. In addition, restraint stress caused dramatic decrease in T help 1 (Th1) cytokine IFN-gamma and IL-2 levels but increase in Th2 cytokine IL-4 in wild type mice. Moreover, the restraint stress significantly inhibits changes of Th1 and Th2 cytokines in TLR4-deficient mice compared with the wild type mice. Therefore, stress modulates the immune system through a TLR4-dependent mechanism.

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Citations

Jul 30, 2010·Neuro-oncology·Adam WuAmy B Heimberger
Jan 14, 2011·Neuroimmunomodulation·Hui LiDeling Yin
Mar 9, 2012·Molecular Medicine·Blake T GurfeinDouglas F Nixon
Feb 12, 2014·Brain, Behavior, and Immunity·Dan HuDeling Yin
Jan 15, 2014·Journal of Neuroinflammation·Iciar GárateJuan Carlos Leza
Jul 26, 2008·Journal of Neuroimmunology·Yi ZhangDeling Yin
May 13, 2008·Neuroscience and Biobehavioral Reviews·Borja García-BuenoJuan C Leza
Apr 2, 2011·Alimentary Pharmacology & Therapeutics·D P McKernanT G Dinan
Aug 7, 2012·Scandinavian Journal of Clinical and Laboratory Investigation·Bård LundelandPer Vaagenes
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Mar 10, 2015·Veterinary Immunology and Immunopathology·E M AbdelfattahS D Eicher
Feb 10, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kathryn X WangDavid T Denhardt
Apr 30, 2019·Brain and Behavior·Chengliang ZhangXianju Zhou
Mar 30, 2021·The Journal of Experimental Biology·Haley E HansonLynn B Martin

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