Toll-like receptor (TLR) and nucleosome-binding oligomerization domain (NOD) gene polymorphisms and endometrial cancer risk.

BMC Cancer
Katie A AshtonRodney J Scott

Abstract

Endometrial cancer is the most common gynaecological malignancy in women of developed countries. Many risk factors implicated in endometrial cancer trigger inflammatory events; therefore, alterations in immune response may predispose an individual to disease. Toll-like receptors (TLRs) and nucleosome-binding oligomerization domain (NOD) genes are integral to the recognition of pathogens and are highly polymorphic. For these reasons, the aim of the study was to assess the frequency of polymorphic variants in TLR and NOD genes in an Australian endometrial cancer population. Ten polymorphisms were genotyped in 191 endometrial cancer cases and 291 controls using real-time PCR: NOD1 (rs2075822, rs2907749, rs2907748), NOD2 (rs5743260, rs2066844, rs2066845), TLR2 (rs5743708), TLR4 (rs4986790) and TLR9 (rs5743836, rs187084). Haplotype analysis revealed that the combination of the variant alleles of the two TLR9 polymorphisms, rs5743836 and rs187084, were protective for endometrial cancer risk: OR 0.11, 95% CI (0.03-0.44), p = 0.002. This result remained highly significant after adjustment for endometrial cancer risk factors and Bonferroni correction for multiple testing. There were no other associations observed for the other polymorph...Continue Reading

References

Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Nov 18, 1997·Cell·R Medzhitov, C A Janeway
Dec 29, 2000·Nature·H HemmiS Akira
Oct 12, 2001·Annals of the New York Academy of Sciences·A AkhmedkhanovP Toniolo
Feb 28, 2002·Annual Review of Immunology·Arthur M Krieg
Dec 15, 2004·Microbes and Infection·Chandrashekhar Pasare, Ruslan Medzhitov
May 10, 2005·International Journal of Cancer. Journal International Du Cancer·Freddie BrayElisabete Weiderpass
Jun 4, 2005·Advances in Experimental Medicine and Biology·Chandrashekhar Pasare, Ruslan Medzhitov
Dec 21, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Francesmary ModugnoNoel S Weiss
Dec 7, 2007·The Journal of Steroid Biochemistry and Molecular Biology·A DollJ Reventós
Dec 29, 2007·The Journal of Pathology·L A M CarneiroL H Travassos
Jan 8, 2008·Oncogene·E M El-OmarG L Hold
Sep 9, 2008·Reproductive Biology and Endocrinology : RB&E·Svenja AllhornIsabella Gashaw
Dec 27, 2008·BMC Bioinformatics·Kim W CarterLyle J Palmer
Feb 6, 2009·Gynecologic Oncology·Katie A AshtonRodney J Scott
Feb 12, 2009·Reproductive Sciences·Gerson WeissHugh S Taylor
May 15, 2009·BJOG : an International Journal of Obstetrics and Gynaecology·K A AshtonR J Scott
Oct 21, 2009·The International Journal of Biochemistry & Cell Biology·Caroline Ospelt, Steffen Gay
Dec 29, 2009·Current Opinion in Genetics & Development·Sergei I Grivennikov, Michael Karin

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Citations

Jun 21, 2012·Molecular Biology Reports·Andrzej RoszakPawel P Jagodziński
Sep 3, 2013·Genetic Testing and Molecular Biomarkers·Xiao-Qin WangKui Zhang
Mar 4, 2014·PloS One·Jingwei LiuYuan Yuan
Mar 20, 2012·Cancer Management and Research·Anton G Kutikhin, Arseniy E Yuzhalin
Jun 11, 2014·Annals of Hematology·Hala Aly Abdel RahmanShirihan Mahmoud Mahgoub
Nov 4, 2011·Cellular and Molecular Life Sciences : CMLS·Li YuShangwu Chen
Jul 13, 2011·Human Immunology·Anton G Kutikhin
Nov 18, 2010·Human Immunology·Anton G Kutikhin
Oct 22, 2016·Current Research in Translational Medicine·E FehriS Boubaker
Feb 29, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Haiyan YangYadong Wang
Oct 24, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Guo-Xing WanFeng Li
Oct 23, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Kui ZhangLin Zhang
Aug 20, 2014·Gynecologic Oncology·Nader Husseinzadeh, Sara Madison Davenport
Apr 23, 2013·International Immunopharmacology·Shirin Moossavi, Nima Rezaei
Jul 15, 2015·World Journal of Gastroenterology : WJG·Marcela Alcântara ProençaAna Elizabete Silva
Oct 17, 2018·Reproductive Biology and Endocrinology : RB&E·Xueying ZhangManhua Cui
Oct 13, 2018·Molecular Diagnosis & Therapy·Nilesh PandeyNeeraj Jain
Feb 23, 2020·Life Sciences·Luiz Antonio LupiLuiz Gustavo de Almeida Chuffa
May 14, 2021·Frontiers in Immunology·Yingchi ZhangWei Lu
Jun 23, 2021·Molecular Diagnosis & Therapy·Dilraj KaurGajendra Pal Singh Raghava
Jul 1, 2021·Molecular Biology Reports·Marília Gonçalves QuirinoJeane Eliete Laguila Visentainer

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Methods Mentioned

BETA
PCR
genotyping

Software Mentioned

SPSS
SIMHAP
Quanto
STATA

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