Toll-like receptors and innate antiviral immunity

Tissue Antigens
Delphine Galiana-Arnoux, J-L Imler

Abstract

Viral infections are first detected by a set of innate immunity receptors that detect primary infections by pathogens, and trigger a transcriptional response. Among the induced target genes, type I interferons (IFNs) are central to the antiviral response of the host. The receptors and signaling pathways that mediate the strong induction of the synthesis of these cytokines have long remained elusive. In the past few years, Toll-like receptors (TLRs) emerged as important sensors of infections. Several TLRs participate in the recognition of virus infection, interacting in particular with viral nucleic acids. Upon activation, TLRs interact with different cytosolic adapter molecules and activate transcription factors of the nuclear factor-kappaB and IFN regulatory factor families that concur to mediate induction of IFN-alpha/beta and other inflammatory cytokines. In addition to the transmembrane TLRs, cytosolic helicases also detect viral nucleic acids, and trigger type I IFN synthesis.

References

Jan 1, 1989·Cold Spring Harbor Symposia on Quantitative Biology·C A Janeway
May 21, 1999·Science·J A HoffmannR A Ezekowitz
Mar 29, 2003·Journal of Virology·Teresa ComptonRobert W Finberg
Apr 15, 2003·Nature Immunology·Katherine A FitzgeraldTom Maniatis
Feb 21, 2004·Science·Sandra S DieboldCaetano Reis e Sousa
Mar 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Koichi TabetaBruce Beutler
Mar 23, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jennifer M LundRichard A Flavell
Apr 28, 2004·Virology·Kurt H EdelmannMichael B A Oldstone
Jun 23, 2004·Trends in Immunology·Hermann Wagner
Jul 2, 2004·Nature Reviews. Immunology·Shizuo Akira, Kiyoshi Takeda
Aug 13, 2004·European Journal of Immunology·Mark RutzStefan Bauer
Oct 27, 2004·Nature Structural & Molecular Biology·Saumendra N SarkarGanes C Sen
Nov 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·J AndrejevaR E Randall
Mar 3, 2005·Proceedings of the National Academy of Sciences of the United States of America·Mario Barro, John T Patton
Mar 16, 2005·The Journal of Experimental Medicine·Julianne StackAndrew G Bowie
Apr 30, 2005·Science·Felix YarovinskyAlan Sher
May 17, 2005·Nature Immunology·Zhengfan JiangBruce Beutler
Jul 5, 2005·Trends in Microbiology·Thomas A KuferDana J Philpott
Jul 20, 2005·The Journal of Experimental Medicine·Sean R ChristensenMark J Shlomchik
Jul 26, 2005·Immunity·Hiroki KatoShizuo Akira
Aug 2, 2005·Nature Cell Biology·Zhijian J Chen
Sep 1, 2005·The Journal of Biological Chemistry·Katherine O OmuetiRichard I Tapping
Oct 18, 2005·Immunity·Peter Kirk, J Fernando Bazan
Nov 2, 2005·The Journal of Experimental Medicine·Christina M LauAnn Marshak-Rothstein
Nov 29, 2005·Trends in Immunology·Cynthia L Johnson, Michael Gale
Jan 18, 2006·Immunity·Daniel B Stetson, Ruslan Medzhitov

❮ Previous
Next ❯

Citations

Mar 24, 2006·Nature Immunology·Delphine Galiana-ArnouxJean-Luc Imler
Mar 1, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·E Angela MurphyJ David Gangemi
Jan 26, 2012·Cellular Signalling·Ao Zhou, Shujun Zhang
Feb 10, 2019·BMC Microbiology·Mohamed Sarjoon Abdul-CaderMohamed Faizal Abdul-Careem

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

The Journal of Allergy and Clinical Immunology
Tsuneyasu Kaisho, Shizuo Akira
Current Molecular Medicine
Ashok Kumar, Fu-Shin X Yu
Proceedings of the National Academy of Sciences of the United States of America
Jared C RoachAlan Aderem
© 2022 Meta ULC. All rights reserved