Toll-like receptors in systemic lupus erythematosus; prospects for therapeutic intervention.

Autoimmunity Reviews
Wan-Uk KimRichard Bucala

Abstract

Recent experimental and clinical studies have placed new emphasis on the role of the innate immune system in SLE. Nucleic acid-containing immune complexes activate the innate response by engaging specific Toll-like receptors (TLRs) and promote the generation of autoantibodies. Pharmacologic modulation of TLR-directed pathways may offer new therapeutic approaches for the treatment of SLE.

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