Tolterodine for the treatment of overactive bladder

Expert Opinion on Pharmacotherapy
Stefano SalvatorePierfrancesco Bolis

Abstract

The overactive bladder syndrome is a common condition affecting approximately 12% of men and women. It is extremely disturbing with a great impact on quality of life. Its treatment involves a combination of behavioural and pharmacological therapy. The latter includes antimuscarinic drugs such as tolterodine. To review the safety and efficacy of tolterodine in the treatment of overactive bladder in comparison with other available antimuscarinic agents. A Pubmed search was carried out differentiating randomised, clinical trials; longitudinal, retrospective studies; and metanalysis on the use of tolterodine for overactive bladder treatment. In the comparison with other antimuscarinic agents, only randomised, clinical trials were considered. Tolterodine is available as immediate- or extended-release formulations. It has been extensively evaluated with long-term, randomised trials for safety and efficacy showing a significant improvement in overactive bladder symptoms with an excellent tolerability profile.

References

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Citations

Jun 21, 2011·Advances in Urology·Anastasios Athanasopoulos, Konstantinos Giannitsas
Jul 9, 2010·Advances in Chronic Kidney Disease·Sarinya BoongirdMark L Unruh
Dec 7, 2019·Pharmacoepidemiology and Drug Safety·Wolfgang UmekGeorg Heinze

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