PMID: 65373Mar 1, 1977Paper

Toluene diisocyanate pulmonary disease: immunopharmacologic and mecholyl challenge studies

The Journal of Allergy and Clinical Immunology
B T ButcherO Garg

Abstract

Selected workers exhibiting clinical "sensitivity" to toluene diiosocyanate (TDI) (wheezing, cough, and dyspnea upon entering a TDI-containing area) were studied for : (1) in vitro TDI-induced leukocyte histamine release; (2) determination of cyclic 3',5' adenosine monophosphate (cAMP) levels of lymphocytes exposed to TDI; (3) effect of TDI on the isoproterenol-induced increase of lymphocyte cAMP levels: and (4) acetyl-beta-methylcholine (mecholyl) inhalation challenge. TDI did not induce histamine release from leukocytes of "sensitive" or "nonsensitive" individuals, nor were lymphocyte cAMP levels affected by in vitro TDI exposure, TDI did, however, diminish in vitro stimulation of cAMP by isoproterenol. This effect, seen with cells of "sensitive" and "nonsensitive" individuals, appeared to be dose-dependent; there were no significant differences between the two groups. When challenged with mecholyl, 7 of 10 "sensitive" but only 1 of 10 "nonsensitive" individuals showed a greater than 20% decrease in FEV1. These results suggest that TDI-induced obstructive airways disorders may be associated with altered beta-adrenergic function.

References

Jun 1, 1975·Environmental Health Perspectives·H WeillM Ziskind
Jul 1, 1976·The Journal of Allergy and Clinical Immunology·B T ButcherM M Ziskind
Jun 1, 1967·Proceedings of the Society for Experimental Biology and Medicine·S Malkiel, B J Hargis
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Mar 1, 1964·American Industrial Hygiene Association Journal·L D SCHEELA JOSEPHSON

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Citations

Aug 1, 1986·Clinical Reviews in Allergy·M Chan-Yeung
Nov 1, 1977·Clinical Allergy·D W CockcroftF E Hargreave
Sep 1, 1980·The Journal of Allergy and Clinical Immunology·J Pepys
Aug 1, 1990·Regulatory Toxicology and Pharmacology : RTP·P J BormP T Henderson
Feb 1, 1988·Chest·M Chan-Yeung
Jan 1, 1986·American Journal of Industrial Medicine·R J ThomasJ H Baker
Jan 1, 1986·Critical Reviews in Toxicology·M H Karol

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