Tomato allergy: detection of IgE-binding lipid transfer proteins in tomato derivatives and in fresh tomato peel, pulp, and seeds

Journal of Agricultural and Food Chemistry
V PravettoniE A Pastorello

Abstract

There is an increasing consumption of tomatoes worldwide: fresh in salads, cooked in household sauces, or industrially processed. Although many tomato allergens have been identified, there is no information in the literature on the allergenic components found in commercial tomato products. The primary aim of the study was to evaluate the allergenic profile of commercial tomato products by skin prick tests (SPTs) and IgE/immunoblotting in tomato-allergic subjects. The secondary end point was the study of the IgE-binding profile of tomato peel, pulp, and seeds. Forty tomato-allergic patients, reporting oral allergy syndrome (OAS) at different grades of severity for fresh and, in some cases, also for cooked tomato, were selected on the basis of positive tomato allergy history or open food challenge (OFC). They were evaluated by SPTs with different experimental tomato extracts. SDS-PAGE/immunoblotting was performed to detect tomato allergens, which were then identified by Edman degradation. Twenty-three patients (57.5%) presented first-grade OAS at the OFC, whereas 17 (42.5%) reported severe symptoms. Ten of these 17 patients (25%) reported allergic reactions to cooked tomatoes; in immunoblotting tests, their sera reacted only to l...Continue Reading

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Citations

Jun 29, 2010·Current Allergy and Asthma Reports·Matthias EggerGabriele Gadermaier
Dec 6, 2012·Journal of Agricultural and Food Chemistry·Elide A PastorelloValerio Pravettoni
May 9, 2014·The Journal of Allergy and Clinical Immunology. in Practice·Alicia ArmentiaJorge Martínez-Quesada
Nov 28, 2012·Clinical Reviews in Allergy & Immunology·R Christopher Van Winkle, Christopher Chang
Aug 2, 2015·Plant Physiology and Biochemistry : PPB·Mariateresa VolpicellaLuigi R Ceci
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Jul 20, 2011·Journal of the Science of Food and Agriculture·Sabine DöllePhilipp Franken
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May 18, 2016·PloS One·Alessandra GhianiMaria Manuela Rigano
Nov 7, 2017·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R AseroV Pravettoni
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Apr 5, 2011·Current Opinion in Allergy and Clinical Immunology·Barbara K Ballmer-Weber, Karin Hoffmann-Sommergruber
Feb 22, 2013·Current Opinion in Allergy and Clinical Immunology·Riccardo Asero, Valerio Pravettoni
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