PMID: 15220675Jun 29, 2004Paper

Tomato-based functional food as interferon adjuvant in HCV eradication therapy

Journal of Clinical Gastroenterology
Filomena MoriscoNicola Caporaso

Abstract

The authors conducted a study to verify whether supplementation with an antioxidant-rich tomato-based functional food reduces anemia during pegylated interferon and ribavirin therapy for chronic hepatitis C. Oxidative stress plays a major role in the physiopathology of hemolytic anemia during ribavirin therapy. The efficacy of antioxidant supplementation with vitamins C and E as pure compounds, is still controversial. A functional food with a high content of natural antioxidants and with high carotenoid bioavailability was developed. The authors enrolled 92 patients with chronic hepatitis C, treated with standard combination therapy. Forty-six of them received a daily dose (100 g) of functional food (group 1), and 46 did not (group 2). The effect of antioxidant activity was assessed comparing compliance with the full dose of ribavirin and hemoglobin levels during the first 3 months of treatment. Only 8.7% of patients in group 1 had to reduce their daily ribavirin dose, whereas ribavirin reduction was necessary for 30.4% of patients in group 2 (P = 0.09). Hemoglobin levels showed significant differences at 15, 30, and 90 days during the observation time. Results demonstrated that the authors' functional food reduces the severity...Continue Reading

References

May 30, 1998·Proceedings of the Society for Experimental Biology and Medicine·G R Beecher
May 30, 1998·Proceedings of the Society for Experimental Biology and Medicine·C La Vecchia
Mar 25, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L De FranceschiR Corrocher
Oct 31, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Michael W Fried

❮ Previous
Next ❯

Citations

Dec 7, 2007·Molecular Aspects of Medicine·Filomena MoriscoNicola Caporaso
Aug 19, 2007·Free Radical Biology & Medicine·Scott SeronelloJinah Choi
Sep 13, 2008·The American Journal of Gastroenterology·Carmela LoguercioMarcello Persico
Mar 4, 2005·Molecular Nutrition & Food Research·Vincenzo Fogliano, Paola Vitaglione
Jun 23, 2005·Critical Reviews in Food Science and Nutrition·Paola VitaglioneVincenzo Fogliano

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.