Tomato oleoresin inhibits DNA damage but not diethylnitrosamine-induced rat hepatocarcinogenesis

Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie
C ScolasticiDaisy Maria Favero Salvadori

Abstract

Various studies have shown that lycopene, a non-provitamin A carotenoid, exerts antioxidant, antimutagenic and anticarcinogenic activities in different in vitro and in vivo systems. However, the results concerning its chemopreventive potential on rat hepatocarcinogenesis are ambiguous. The aim of the present study was to investigate the antigenotoxic and anticarcinogenic effects of dietary tomato oleoresin adjusted to lycopene concentration at 30, 100 or 300 ppm (administered 2 weeks before and during or 8 weeks after carcinogen exposure) on liver of male Wistar rats treated with a single intraperitoneal dose of 20 or 100mg/kg of diethylnitrosamine (DEN), respectively. The level of DNA damage in liver cells and the development of putative preneoplastic single hepatocytes, minifoci and foci of altered hepatocytes (FHA) positive for glutathione S-transferase (GST-P) were used as endpoints. Significant reduction of DNA damage was detected when the highest lycopene concentration was administered before and during the DEN exposure (20mg/kg). However, the results also showed that lycopene consumption did not reduce cell proliferation in normal hepatocytes or the growth of initiated hepatocytes into minifoci positive for GST-P during ...Continue Reading

References

Apr 1, 1991·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·Y P DraganH C Pitot
Mar 1, 1987·Carcinogenesis·M A MooreK Sato
Oct 7, 2000·Journal of the American College of Nutrition·A V Rao, S Agarwal
Jun 18, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S Knasmüller, H Verhagen
Jun 18, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Young-Joon Surh
Aug 15, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·W MellertR Slesinski
Aug 12, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Vibeke M BreinholtLars O Dragsted
Sep 10, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A R AgnerD M F Salvadori
Nov 25, 2005·Current Medicinal Chemistry. Anti-cancer Agents·V Bhuvaneswari, S Nagini
Mar 28, 2006·Biochemical Pharmacology·Bharat B Aggarwal, Shishir Shishodia
Apr 6, 2006·Journal of the National Cancer Institute·Jian-Min YuanMimi C Yu
Mar 14, 2007·Toxicology in Vitro : an International Journal Published in Association with BIBRA·C ScolasticiD M F Salvadori
May 15, 2007·Mutation Research·Ana Lucia Anjos FerreiraMarcelo Sady Plácido Ladeira
Dec 14, 2007·Toxicology in Vitro : an International Journal Published in Association with BIBRA·C ScolasticiD M F Salvadori

❮ Previous
Next ❯

Citations

Apr 3, 2012·Mutation Research·Amaya Azqueta, Andrew R Collins
Jan 26, 2010·Experimental and Molecular Pathology·S W French
Mar 23, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Chin-Shiu Huang, Miao-Lin Hu
Dec 23, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Marcos C DiasLuis F Barbisan
Sep 14, 2016·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Paula Martins LarangeiraDaniel Araki Ribeiro

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenocortical Carcinoma

Hepatocellular carcinoma is the most common type of primary liver cancer and frequently occurs in individuals with chronic liver diseases like cirrhosis. Here is the latest research.

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.