Tomoelastography Paired With T2* Magnetic Resonance Imaging Detects Lupus Nephritis With Normal Renal Function

Investigative Radiology
Stephan Rodrigo Marticorena GarciaJing Guo

Abstract

The aim of this study was to test multiparametric magnetic resonance imaging including blood oxygen level-dependent (BOLD) imaging by T2* mapping, magnetic resonance elastography (MRE) by tomoelastography, and diffusion-weighted imaging (DWI) for detecting nephropathy in patients with lupus nephritis (LN). Forty-one subjects (25 patients with LN and 16 age- and sex-matched healthy volunteers; LN: mean age, 47.3 ± 14.8 years; 22 female subjects; volunteers: mean age, 43.9 ± 11.6 years; 13 female subjects) were prospectively enrolled. The LN group was further divided into subgroups with normal (LN-nRF, GFR > 90 mL/min per 1.73 m) and compromised renal function (LN-cRF, GFR < 90 mL/min per 1.73 m). All subjects were examined by multifrequency MRE, BOLD imaging, and DWI, yielding shear wave speed (SWS; in meter per second), T2* relaxation times (in millisecond), and apparent diffusion coefficient (ADC; in millimeter square per second), respectively. Renal subregional analysis was performed for the medulla (ME), inner cortex (CoI), and outer cortex (CoO). Imaging markers were correlated to clinical parameters such as GFR and protein-to-urine creatinine ratio. Cutoffs and area under the receiver operating curve (AUROC) were computed ...Continue Reading

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Citations

Jul 2, 2019·Investigative Radiology·Kai JiangLilach O Lerman
Jul 13, 2019·Investigative Radiology·Lars-Arne SchaafsThomas Elgeti
Jul 2, 2019·Investigative Radiology·Sophia Theresa LangStephan Rodrigo Marticorena Garcia
Mar 7, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Joaquin MuraIngolf Sack
Jan 28, 2020·Investigative Radiology·Christian BurkhardtStephan Rodrigo Marticorena Garcia
Oct 27, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Mehrgan ShahryariIngolf Sack
Oct 12, 2021·Frontiers in Physiology·Seyed M SeyedpourTim Ricken

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