PMID: 9420778Mar 1, 1995Paper

Tomographic and planar quantitation of perfusion defects on technetium 99m-labeled sestamibi scans: evaluation in patients treated with thrombolytic therapy for acute myocardial infarction

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
L A MortelmansF J Van de Werf

Abstract

Our segmentation algorithm for single-photon emission computed tomographic perfusion studies was tested in 244 patients treated by thrombolysis within 5 hours after onset of symptoms. This algorithm uses radial slices to approximate true three-dimensional gradients, determines the apex and basal plane, and creates a perfusion and volume polar map. Perfusion defect size was compared with enzymatic infarct size and global and regional function. All patients underwent rest planar and tomographic 99mTc-labeled sestamibi scanning, contrast coronary angiography, and ventriculography 10 to 14 days after the start of treatment. Manual correction had to be performed in only 10% of the cases and presented no problems. The correlation coefficients (r) between planar and relative tomographic perfusion defects versus enzymatic infarct size were 0.71 and 0.73. A negative correlation was found with left ventricular ejection fraction: r = -0.65 and r = -0.60. A comparable correlation was also found between regional wall motion and perfusion defect size. Most correlations were higher in the case of anterior infarction. An excellent correlation was found between planar and tomographic defect size (r = 0.83). In most cases, our segmentation algor...Continue Reading

References

Jun 14, 1979·The New England Journal of Medicine·G A Diamond, J S Forrester
Oct 16, 1990·The American Journal of Cardiology·E V GarciaN Ezquerra
Jan 1, 1987·Cardiovascular and Interventional Radiology·E V GarciaE E DePasquale
Nov 1, 1985·The American Journal of Cardiology·C L WolfeJ T Willerson
Jan 1, 1991·IEEE Transactions on Medical Imaging·J NuytsL Mortelmans

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