PMID: 15223806Jun 30, 2004Paper

Tomographic identification of neuroretinal rim loss in high-pressure, normal-pressure, and suspected glaucoma

Investigative Ophthalmology & Visual Science
James C H TanRoger A Hitchings

Abstract

To identify progressive rim loss and describe patterns of regional change in various clinical presentations of glaucoma by scanning laser tomography (SLT). A previously described analytical approach was used to identify progressive rim area loss in SLT disc images of eyes of people with ocular hypertension (OHT, n = 97), early POAG (OHT converters; n = 30), asymmetric normal-pressure glaucoma (NPG, established and suspected in contralateral eyes; n = 26), and normal control subjects (n = 32). Analysis was performed longitudinally in individual image series, and cross-sectionally within groups at different time points. Reproducibly reduced rim area was detected in 2 (6.2%) of 32 normal control subjects, 11 (11%) of 97 OHT subjects, 27 (90%) of 30 OHT converters, 16 (58%) of 26 of suspected NPG eyes, and 15 (54%) of 26 of established NPG eyes (mean MD = -6.5 dB). Of 5 (19%) of 26 of suspected NPG eyes that converted on visual field testing, rim loss was detected in 3 of 5. In all groups, rim loss was common in the disc poles, especially inferiorly. Patterns of rim loss were similar within high-pressure and normal-pressure groups, whether or not eyes had field defects in each. In high-pressure groups, rim loss was more common nasa...Continue Reading

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