Tone-Evoked Acoustic Change Complex (ACC) Recorded in a Sedated Animal Model

Journal of the Association for Research in Otolaryngology : JARO
Alessandro Presacco, John C Middlebrooks

Abstract

The acoustic change complex (ACC) is a scalp-recorded cortical evoked potential complex generated in response to changes (e.g., frequency, amplitude) in an auditory stimulus. The ACC has been well studied in humans, but to our knowledge, no animal model has been evaluated. In particular, it was not known whether the ACC could be recorded under the conditions of sedation that likely would be necessary for recordings from animals. For that reason, we tested the feasibility of recording ACC from sedated cats in response to changes of frequency and amplitude of pure-tone stimuli. Cats were sedated with ketamine and acepromazine, and subdermal needle electrodes were used to record electroencephalographic (EEG) activity. Tones were presented from a small loudspeaker located near the right ear. Continuous tones alternated at 500-ms intervals between two frequencies or two levels. Neurometric functions were created by recording neural response amplitudes while systematically varying the magnitude of steps in frequency centered in octave frequency around 2, 4, 8, and 16 kHz, all at 75 dB SPL, or in decibel level around 75 dB SPL tested at 4 and 8 kHz. The ACC could be recorded readily under this ketamine/azepromazine sedation. In contra...Continue Reading

References

Aug 1, 1978·Electroencephalography and Clinical Neurophysiology·M KohnD Litchfield
Jul 1, 1978·Acta Psychologica·R NäätänenS Mäntysalo
Dec 1, 1976·Acta Physiologica Scandinavica·S D ArlingerE C Holmgren
Mar 1, 1988·Anaesthesia·G SavoiaR Cuocolo
Jan 1, 1985·Hearing Research·R S Heffner, H E Heffner
Jan 1, 1973·Archiv für klinische und experimentelle Ohren- Nasen- und Kehlkopfheilkunde·A Sokolovski
Mar 1, 1968·The Journal of the Acoustical Society of America·J L Hall, M H Goldstein
Dec 1, 1983·The International Journal of Neuroscience·C D Yingling, G E Nethercut
Jan 1, 1993·The Journal of the Acoustical Society of America·R D HienzC M Aleszczyk
May 2, 2000·The Journal of the Acoustical Society of America·B A Martin, A Boothroyd
Jan 1, 1957·Journal of Neurophysiology·R A BUTLERW D NEFF
Jun 1, 1965·The Annals of Otology, Rhinology, and Laryngology·D N ELLIOTT, T M MCGEE
Mar 2, 2005·PLoS Biology·G Christopher SteckerJohn C Middlebrooks
Feb 1, 2007·Journal of the Association for Research in Otolaryngology : JARO·John C Middlebrooks, Russell L Snyder
Apr 28, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jemma Hine, Stefan Debener
Jul 26, 1991·Science·B Efron, R Tibshirani
May 20, 2008·Hearing Research·John C Middlebrooks, Russell L Snyder
Jul 19, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Andrew DimitrijevicArnold Starr
Dec 30, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Andrew DimitrijevicArnold Starr
Feb 5, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·John C Middlebrooks, Russell L Snyder
Sep 9, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Andrew DimitrijevicHillel Pratt
Sep 25, 2012·International Journal of Audiology·Shuman HeCraig A Buchman
Jan 1, 2013·Seminars in Hearing·Amy S MartinezArthur Boothroyd
Feb 7, 2015·Ear and Hearing·Rachel A Scheperle, Paul J Abbas
Jan 23, 2016·International Journal of Otolaryngology·Ke Heng Chen, Susan A Small

❮ Previous
Next ❯

Citations

Jun 7, 2019·Journal of the Association for Research in Otolaryngology : JARO·Bernard M D VonckHuib Versnel
Mar 2, 2021·Hearing Research·Robin GransierJan Wouters

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.