Tongkyutang inhibits mast cell-dependent allergic reactions and inflammatory cytokines secretion

Clinica Chimica Acta; International Journal of Clinical Chemistry
Ho-Jeong NaHyung-Min Kim

Abstract

Tongkyutang (TKT) is an Oriental herbal prescription, which has been successfully applied for the treatment of allergic disorders, mainly allergic-rhinitis in clinical medicine. However, its effect in experimental models remains unknown. In a mouse model, the role of TKT was examined in mast cell-dependent allergic reactions and secretion of inflammatory cytokines. TKT concentration-dependently inhibited the ear-swelling response induced by intradermal injection of compound 48/80. TKT inhibited the compound 48/80-induced degranulation from mast cells in ear tissue. TKT dose-dependently inhibited the histamine release from the rat peritoneal mast cells by compound 48/80. TKT also showed inhibition of anti-dinitrophenyl IgE antibody-induced passive cutaneous anaphylaxis reaction by oral administration. Furthermore, TKT inhibited both IL-1beta and TNF-alpha secretion induced by PMA and A23187, respectively. Our findings provide evidence that TKT inhibits the mast cell-dependent allergic reactions and inflammatory cytokines secretion.

References

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Mar 12, 1999·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·H M KimK S Lim
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Citations

Aug 28, 2007·In Vitro Cellular & Developmental Biology. Animal·In-Young ChoiSeung-Heon Hong
Mar 24, 2004·Journal of Ethnopharmacology·Hye-Young ShinHyung-Min Kim
Apr 9, 2005·Journal of Ethnopharmacology·Seung-Heon HongHyung-Min Kim
May 17, 2005·Journal of Ethnopharmacology·Ho-Jeong NaHyung-Min Kim
Dec 11, 2013·ISRN Allergy·Ibrahim SayinSeckin Ulusoy
Feb 9, 2005·Journal of Pharmacological Sciences·Ho-Jeong NaHyung-Min Kim
Jun 24, 2004·Immunopharmacology and Immunotoxicology·Ho-Jeong NaHyung-Min Kim
Sep 7, 2011·International Archives of Allergy and Immunology·M S CastroM A Manghi
Nov 3, 2004·Immunopharmacology and Immunotoxicology·Ho-Jeong NaHyung-Min Kim
Nov 8, 2005·International Archives of Allergy and Immunology·Ho-Jeong NaHyung-Min Kim
Oct 30, 2008·Journal of Immunotoxicology·Shailaja G Mahajan, Anita A Mehta

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