Tongxinluo Improves Apolipoprotein E-Deficient Mouse Heart Function

Chinese Medical Journal
Guo-Qiang YuanYi-Ling Wu

Abstract

Our previous studies have shown that Tongxinluo (TXL), a compound Chinese medicine, can decrease myocardial ischemia-reperfusion injury, protect capillary endothelium function, and lessen cardiac ventricle reconstitution in animal models. The aim of this study was to illuminate whether TXL can improve hypercholesterolemia-impaired heart function by protecting artery endothelial function and increasing microvascular density (MVD) in heart. Furthermore, we will explore the underlying molecular mechanism of TXL cardiovascular protection. After intragastric administration of TXL (0.1 ml/10 g body weight) to C57BL/6J wild-type mice (n = 8) and ApoE-/- mice (n = 8), total cholesterol, high-density lipoprotein-cholesterol, very-low-density lipoprotein (VLDL)-cholesterol, triglyceride, and blood glucose levels in serum were measured. The parameters of heart rate (HR), left ventricular diastolic end diameter, and left ventricular systolic end diameter were harvested by ultrasonic cardiogram. The left ventricular ejection fraction, stroke volume, cardiac output, and left ventricular fractional shortening were calculated. Meanwhile, aorta peak systolic flow velocity (PSV), end diastolic flow velocity, and mean flow velocity (MFV) were mea...Continue Reading

References

Nov 30, 2000·Proceedings of the National Academy of Sciences of the United States of America·H SuY W Kan
Aug 18, 2006·Basic Research in Cardiology·Thorsten Reffelmann, Robert A Kloner
May 3, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Eric E LloydRobert M Bryan

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Citations

Feb 10, 2020·Lipids in Health and Disease·Yu Si YaoZhi Huan Zeng

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Methods Mentioned

BETA
PCR
electrophoresis
Protein Assay

Software Mentioned

Photoshop
PowerLab
ImageJ
Beacon Designer
SPSS

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