Tongxinluo reduces brain edema and inhibits post-ischemic inflammation after middle cerebral artery occlusion in rats

Journal of Ethnopharmacology
Min CaiDing-Fang Cai

Abstract

Tongxinluo (TXL), a widely used traditional Chinese medicine, has been proved multiple therapeutic effects in cerebral ischemic infraction. The purpose of this study was to investigate the protective effects of TXL on the brain edema and post-ischemic inflammatory response. Middle cerebral artery occlusion in the rat was used as the ischemia model. Rats were treated with TXL. In the first stage, the best dosage was chosen based on functional assessment and infarct size. In the second stage, rats were randomly divided into 5 groups: sham control (sham), ischemia and reperfusion (IR) 24h, TXL24h, I/R72h, TXL72h. TXL(1.6g/kg/day) administration was pre-performed for 3 days in TXL groups, and was post-performed for 24h (TXL24h group) or 72h (TXL72h group). Brain edema was measured by water content, MRI and AQP4 expression. Iba1, HMGB1, TLR4, NF-κB expression were examined by immunofluorescence staining or Western blot. TNF-α was determined by enzyme-linked immunosorbent assay. High dose (1.6g/kg/day) of TXL remarkably reduced neurological deficit scores and cerebral infarct area. Compared with those results of I/R24h group, pre-post treatment with TXL for 3 days decreased brain water content, down-regulated AQP4 expression, lowered...Continue Reading

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Citations

Dec 2, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Min CaiDingfang Cai
Sep 29, 2017·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Xiujian XuMing Yu
Feb 29, 2020·Cellular and Molecular Neurobiology·Shuisheng LeiXiaoqin Zhu
Jan 16, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Lalita Subedi, Bhakta Prasad Gaire
Jan 12, 2021·Technology and Health Care : Official Journal of the European Society for Engineering and Medicine·Gen LiMingsheng Chen
Feb 23, 2021·Frontiers in Aging Neuroscience·Yi YaoJianzhao Luo
Oct 1, 2020·Pharmacology & Therapeutics·Tao TaoJohn H Zhang

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