Tonic activity of alpha1 adrenergic receptors of the medial preoptic area contributes towards increased sleep in rats

Neuroscience
R VetrivelanV M Kumar

Abstract

Several studies have suggested that noradrenergic afferents to the medial preoptic area might be involved in hypnogenesis and in lowering the body temperature, and that the alpha1 adrenergic receptors might be mediating these responses. This study was undertaken to find out the changes in sleep-wakefulness and body temperature in rats, when these adrenergic receptors of the medial preoptic area are blocked by alpha1 selective antagonist, prazosin. Adult male Wistar rats were chronically implanted with electrooculogram, electroencephalogram and electromyogram electrodes for sleep-wakefulness assessment, and a bilateral guide cannula for microinjection of prazosin at the medial preoptic area. A radio-transmitter was implanted in the abdomen for telemetric measurement of body temperature in four groups of rats. Sleep-wakefulness was also assessed telemetrically in four other groups of rats. Sleep-wakefulness recordings from these rats were done in a specialized chamber, where they could move about freely and select the ambient temperature which they prefer. Prazosin induced a dose dependent increase in wake period and in body temperature, when microinjected into the medial preoptic area. Results suggest that preoptic alpha1 adrene...Continue Reading

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Citations

Aug 2, 2014·Behavioural Brain Research·Dayalan SampathT R Laxmi
Mar 8, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·John Studd, Rossella E Nappi
Feb 3, 2012·Sleep Medicine Reviews·Craig W BerridgeRodrigo A España
Mar 8, 2016·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Fatih KayhanAyşegül Kayhan
May 12, 2009·Neuroscience and Biobehavioral Reviews·Florent G RevelJean-Luc Moreau
Jan 18, 2008·Brain Research Reviews·Craig W Berridge
Sep 24, 2013·Physiology & Behavior·Karuna DattaHruda Nanda Mallick
Aug 26, 2006·Neurochemical Research·Velayudhan Mohan KumarHruda Nanda Mallick

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