Tonic and dynamic gonadotropin secretion in depressive and normothymic phases of affective disorders

Psychiatry Research
F BrambillaM Catalano

Abstract

Baseline follicle stimulating hormone (FSH) and luteinizing hormone (LH) plasma levels and their responses to luteinizing hormone releasing hormone (LHRH) stimulation were investigated in 72 patients who met Research Diagnostic Criteria for affective disorders and in 72 healthy volunteers. Fifty-six patients were examined during a depressive phase and 16 during a normothymic phase. LH-FSH basal levels were significantly lower in postmenopausal depressed and normothymic women than in controls. In fertile women and men, concentrations of the two gonadotropins were also lower in patients than in controls, but the phenomenon did not generally reach statistical significance. LHRH-induced LH rises were lower in postmenopausal and fertile depressed and normothymic women than in controls, while FSH rises were reduced only in postmenopausal depressive women in both depressed and normothymic phases. The impairment underlying the gonadotropin secretory deficiency remains to be elucidated.

References

Aug 1, 1977·Acta Endocrinologica·A AroR Pelkonen
Oct 1, 1978·Archives of General Psychiatry·F BrambillaE E Müller
Jun 1, 1975·Journal of Steroid Biochemistry·B S McEwenE R de Kloet
May 1, 1979·Psychosomatic Medicine·P G EttigiJ A Seggie
May 1, 1975·Psychosomatic Medicine·N AltmanS Eto
Aug 1, 1988·Acta Psychiatrica Scandinavica·F UndénL Wetterberg
Jan 1, 1987·Gastrointestinal Radiology·F L HoffG M Glazer
Feb 1, 1985·Biological Psychiatry·J A YesavageP A Berger
Jan 1, 1973·Archives of General Psychiatry·E J SacharL Hellman
May 1, 1983·Archives of General Psychiatry·J D AmsterdamK Rickels
Jan 1, 1983·Acta Psychiatrica Scandinavica·J D AmsterdamP Snyder
Dec 1, 1981·Journal of Affective Disorders·J D AmsterdamP Snyder
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON

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Citations

Nov 10, 1998·Biological Psychiatry·H Joffe, L S Cohen
Apr 5, 2003·Neuroscience Letters·In-Young YoonShawn D Youngstedt
Oct 18, 2002·Psychoneuroendocrinology·P J SchmidtL St Clair
Apr 18, 2009·Harvard Review of Psychiatry·Veronica HarshPeter J Schmidt
Jan 2, 2007·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·R ZanardiE Smeraldi
Nov 13, 2009·Annals of the New York Academy of Sciences·Peter J Schmidt, David R Rubinow
Jun 12, 2002·Endocrinology and Metabolism Clinics of North America·Elizabeth A Young, Ania Korszun
Oct 31, 2002·Human Psychopharmacology·Albert Michael, Veronica O'Keane
Jul 25, 2009·Journal of Psychiatric Practice·Fahd Aziz ZarroufMartin Kommor
Mar 24, 2020·Acta Pharmacologica Sinica·Wen-Kai BiZhao He
Aug 26, 2021·Curēus·Jaskamal PaddaGutteridge Jean-Charles

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