Tonic control of kisspeptin release in prepubertal monkeys: implications to the mechanism of puberty onset.

Endocrinology
Joseph R KurianEi Terasawa

Abstract

Previously we have shown that a reduction in γ-amino butyric acid (GABA) inhibition is critical for the mechanism initiating puberty onset because chronic infusion of the GABA(A) receptor antagonist, bicuculline, significantly increased GnRH release and accelerated the timing of menarche and first ovulation in female rhesus monkeys. Because previous studies in our laboratory indicate that in prepubertal female monkeys, kisspeptin release in the medial basal hypothalamus is low, whereas kisspeptin-10 can stimulate GnRH release, we hypothesized that a low level of kisspeptin release prior to puberty onset is due to tonic GABA inhibition. To test this hypothesis we examined the effects of bicuculline infusion on kisspeptin release using a microdialysis method. We found that bicuculline at 1 μM dramatically stimulates kisspeptin release in the medial basal hypothalamus of prepubertal monkeys but had little effect on kisspeptin release in midpubertal monkeys. We further examined whether bicuculline-induced GnRH release is blocked by the presence of the kisspeptin antagonist, peptide 234. We found that inhibition of kisspeptin signaling blocked the bicuculline-induced stimulation of GnRH release, suggesting that kisspeptin neurons ma...Continue Reading

References

Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·D MitsushimaE Terasawa
May 17, 2000·Proceedings of the National Academy of Sciences of the United States of America·M El MajdoubiT M Plant
Jan 16, 2003·Physiology & Behavior·Tony M Plant, Muhammad Shahab
Aug 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·Nicolas de RouxEdwin Milgrom
Oct 24, 2003·The New England Journal of Medicine·Stephanie B SeminaraWilliam H Colledge
Dec 4, 2003·Biochemical and Biophysical Research Communications·Sandrine FunesEric L Gustafson
Aug 3, 2005·Neuroscience and Biobehavioral Reviews·P E Honess, C M Marin
Jun 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Xavier d'Anglemont de TassignyWilliam H Colledge
Jun 28, 2007·Endocrinology·Risto LapattoStephanie B Seminara
Jul 20, 2007·The Journal of Clinical Endocrinology and Metabolism·Waljit S DhilloStephen R Bloom

❮ Previous
Next ❯

Citations

Mar 20, 2013·Proceedings of the National Academy of Sciences of the United States of America·Han Kyoung ChoeKyungjin Kim
Feb 15, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Renata FrazãoCarol F Elias
Sep 20, 2012·European Journal of Endocrinology·Manuel Tena-Sempere
Dec 17, 2014·Frontiers in Neuroscience·Miho WatanabeJunichi Nabekura
Jul 9, 2016·Current Opinion in Pediatrics·Sarantis Livadas, George P Chrousos
Mar 17, 2018·The Journal of Endocrinology·Luba SominskySarah J Spencer
Dec 21, 2017·Reproductive Medicine and Biology·Haruhiko KanasakiSatoru Kyo
Apr 2, 2020·Animals : an Open Access Journal From MDPI·Wenyu SiFugui Fang
Aug 29, 2017·PloS One·Daniel A AdekunbiKevin T O'Byrne
Apr 24, 2018·Frontiers in Endocrinology·Ei TerasawaKim L Keen
Sep 27, 2012·American Journal of Physiology. Endocrinology and Metabolism·David García-GalianoManuel Tena-Sempere
Dec 4, 2020·Molecular and Cellular Endocrinology·Matteo SpazianiAntonio F Radicioni

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.