Tonic differential supraspinal modulation of PAD and PAH of segmental and ascending intraspinal collaterals of single group I muscle afferents in the cat spinal cord

Experimental Brain Research
P RudominJorge N Quevedo

Abstract

We compared in the anesthetized cat the effects of reversible spinalization by cold block on primary afferent depolarization (PAD) and primary afferent hyperpolarization (PAH) elicited in pairs of intraspinal collaterals of single group I afferents from the gastrocnemius nerve, one of the pairs ending in the L3 segment, around the Clarke's column nuclei, and the other in the L6 segment within the intermediate zone. PAD in each collateral was estimated by independent computer-controlled measurement of the intraspinal current required to maintain a constant probability of antidromic firing. The results indicate that the segmental and ascending collaterals of individual afferents are subjected to a tonic PAD of descending origin affecting in a differential manner the excitatory and inhibitory actions of cutaneous and joint afferents on the pathways mediating the PAD of group I fibers. The PAD-mediating networks appear to function as distributed systems whose output will be determined by the balance of the segmental and supraspinal influences received at that moment. It is suggested that the descending differential modulation of PAD enables the intraspinal arborizations of the muscle afferents to function as dynamic systems, in whi...Continue Reading

References

Feb 1, 1976·The Journal of Physiology·P D Wall, R Werman
Jan 1, 1992·Progress in Neurobiology·E Jankowska
Jul 1, 1997·Experimental Brain Research·J QuevedoP Rudomin
Nov 7, 1999·Experimental Brain Research·P Rudomin, R F Schmidt
Sep 1, 1963·Acta Physiologica Scandinavica·D CARPENTERU NORRSELL
Dec 1, 1963·Acta Physiologica Scandinavica·D CARPENTERA LUNDBERG
Nov 20, 2003·Nature Neuroscience·Kazuhiko SekiEberhard E Fetz

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Citations

Mar 27, 2009·Experimental Brain Research·Pablo Rudomin
Oct 2, 2015·The Journal of Clinical Investigation·Yi ZhangFan Wang
Aug 13, 2013·PloS One·Yunuen Moreno-LópezGerardo Rojas-Piloni
Mar 30, 2016·Annual Review of Neuroscience·Jens Bo Nielsen
Dec 24, 2005·Physiological Reviews·Serge RossignolJean-Pierre Gossard

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