Tonic gravity changes alter gene expression in the efferent vestibular nucleus

Neuroreport
E BalabanO Pompeiano

Abstract

To assess effects of tonic gravity changes on efferent vestibular neurons, immediate early gene (IEG) protein expression was compared in the efferent vestibular nucleus (EVe) of adult rats exposed to microgravity during the NASA Neurolab Mission (STS-90), and matching control animals on the ground. Rats sacrificed 1 day and 12 days after launch (experiencing approximately 0g) showed significantly fewer IEG protein-expressing cells than corresponding ground control animals (at 1 g). Normal IEG protein-expressing cell numbers reappeared within I day after flight animals returned to earth, and were maintained at 14 days after landing. EVe neurons appear to play a role in gravity-induced modifications of vestibular hair cell synapses; a contribution to gravity-induced plasticity of the vestibulo-ocular reflex (VOR) is also suggested.

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Citations

Dec 31, 2003·Brain Research Bulletin·Paola d'AscanioOttavio Pompeiano
Oct 30, 2016·Neuroscience and Biobehavioral Reviews·Viktor S KokhanAndrey S Shtemberg
Jul 15, 2003·Neuroreport·Claude J DechesneJacqueline Raymond
Mar 27, 2021·Neuroscience and Biobehavioral Reviews·Anastasia KharlamovaSergey Saveliev

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