Tonicity effects on intact single muscle fibers: relation between force and cell volume

Science
J Gulati, A Babu

Abstract

Contraction of isolated, intact frog muscle fibers under increasing tonicity of the external solution was studied by adding (i) effectively impermeant sodium chloride and sucrose and (ii) permeant potassium chloride. Force of isometric contraction decreased as a function of tonicity, independent of the permeability of the solute. In contrast, cell volume changed with tonicity in impermeant solutes and was constant with potassium chloride. The results are evidence that ionic strength in the sarcoplasm directly influences the contraction mechanism. Also, the findings show that force development is unaffected by changes in fiber volume, suggesting that the force per cross-bridge is constant at different distances between the thin and myofilaments. Finally, in light of the length-force relation, the results support the idea that cross-bridges are independent force generators.

References

Nov 1, 1978·The Journal of General Physiology·J Gulati, R J Podolsky
Aug 25, 1978·Journal of Molecular Biology·A Elliott, G Offer
Jun 20, 1969·Science·H E Huxley
Feb 1, 1973·The Journal of General Physiology·J Lännergren, J Noth
Apr 1, 1973·The Japanese Journal of Physiology·T Sakai, T Yoshioka
Apr 1, 1973·The Journal of General Physiology·E W April, P W Brandt
Oct 22, 1971·Nature·A F Huxley, R M Simmons
May 1, 1966·The Journal of Physiology·A M GordonF J Julian
May 1, 1981·Pflügers Archiv : European journal of physiology·D W Maughan, R E Godt
Sep 1, 1981·The Journal of General Physiology·J Gulati, R J Podolsky
Aug 11, 1941·The Journal of Physiology·P J Boyle, E J Conway
Jan 1, 1982·Biophysical Journal·F L SuddathJ C Fontecilla-Camps

❮ Previous
Next ❯

Citations

Oct 1, 1986·Pflügers Archiv : European journal of physiology·E W April, D W Maughan
Nov 21, 1989·Journal of Theoretical Biology·N Bachouchi, J E Morel
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S LovellW F Harrington
Jan 13, 2009·Biological Reviews of the Cambridge Philosophical Society·Juliet A Usher-SmithJames A Fraser
Dec 24, 2009·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Naomi M CermakBrian D Roy
Apr 15, 2006·The Journal of Physiology·Juliet A Usher-SmithChristopher L-H Huang
Jun 19, 2012·Journal of Muscle Research and Cell Motility·H RootsK W Ranatunga
Sep 23, 2003·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·Aidar R GosmanovDonald B Thomason
Feb 1, 1992·Journal of Muscle Research and Cell Motility·T C Irving, B M Millman
Apr 30, 1998·Physiological Reviews·B M Millman
Jan 20, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·AnaMaria AntolicBrian D Roy
Jan 1, 1984·The American Journal of Physiology·R E GodtA M Gordon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.