Tonicity-responsive enhancer binding protein is an essential regulator of aquaporin-2 expression in renal collecting duct principal cells

Journal of the American Society of Nephrology : JASN
Udo HaslerPierre-Yves Martin

Abstract

Tonicity-responsive enhancer binding protein (TonEBP) plays a key role in protecting renal cells from hypertonic stress by stimulating transcription of specific genes. Under hypertonic conditions, TonEBP activity is enhanced via increased nuclear translocation, transactivation, and abundance. It was reported previously that hypertonicity exerted a dual, time-dependent effect on vasopressin-inducible aquaporin-2 (AQP2) expression in immortalized mouse collecting duct principal cells (mpkCCDcl4). Whereas AQP2 abundance decreased after 3 h of hyperosmotic challenge, it increased after 24 h of hypertonic challenge. This study investigated the role that TonEBP may play in these events by subjecting mpkCCDcl4 cells to 3 or 24 h of hypertonic challenge. Hypertonic challenge increased TonEBP mRNA and protein content and enhanced TonEBP activity as illustrated by both increased TonEBP-dependent luciferase activity and mRNA expression of several genes that are targeted by TonEBP. Irrespective of the absence or presence of vasopressin, decreased TonEBP activity in cells that were transfected with either TonEBP small interfering RNA or an inhibitory form of TonEBP strongly reduced AQP2 mRNA and protein content under iso-osmotic conditions ...Continue Reading

References

Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S NielsenH W Harris
Jun 1, 1996·The American Journal of Physiology·S HozawaD A Ausiello
Apr 15, 1997·The Journal of Clinical Investigation·C A EcelbargerJ G Verbalis
Apr 1, 1997·The Journal of Clinical Investigation·D L XuR W Schrier
Jun 1, 1997·Journal of the American Society of Nephrology : JASN·Y MatsumuraF Marumo
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·H MiyakawaH M Kwon
May 8, 1999·Journal of the American Society of Nephrology : JASN·M BensA Vandewalle
Jun 3, 2000·American Journal of Physiology. Renal Physiology·S K WooH M Kwon
Jul 15, 2000·American Journal of Physiology. Renal Physiology·L PreisserJ M Verbavatz
Sep 21, 2000·The Journal of Biological Chemistry·Y NakayamaS M Bagnasco
Oct 13, 2001·The Journal of Biological Chemistry·V SummaE Féraille
Oct 25, 2001·Journal of the American Society of Nephrology : JASN·Jung H ChaH Moo Kwon
Jan 5, 2002·Physiological Reviews·Søren NielsenMark A Knepper
Jan 10, 2002·The Journal of Biological Chemistry·Udo HaslerPierre-Yves Martin
Jan 17, 2002·Proceedings of the National Academy of Sciences of the United States of America·Joan D FerrarisMaurice B Burg
Jul 26, 2002·Molecular and Cellular Biology·Seung Kyoon WooH Moo Kwon
Aug 24, 2002·Pflügers Archiv : European journal of physiology·Seung Kyoon WooH Moo Kwon
Oct 22, 2002·American Journal of Physiology. Renal Physiology·R StormK Maric
Mar 28, 2003·The Journal of Biological Chemistry·Udo HaslerPierre-Yves Martin
Sep 13, 2003·The Journal of Biological Chemistry·Sang Do LeeH Moo Kwon
Feb 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Cristina López-RodríguezEric N Olson
Sep 7, 2004·The Journal of Biological Chemistry·Amy K M LamStephen S M Chung
Oct 21, 2004·American Journal of Physiology. Renal Physiology·Mauro BustamanteEric Féraille
Apr 22, 2005·Journal of the American Society of Nephrology : JASN·Udo HaslerEric Féraille
Jun 24, 2005·American Journal of Physiology. Renal Physiology·David MordasiniEric Féraille
Jun 30, 2005·American Journal of Physiology. Renal Physiology·Udo HaslerPierre-Yves Martin
Oct 12, 2005·The Journal of Biological Chemistry·Rama SoundararajanDavid Pearce

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Citations

Apr 24, 2008·Pflügers Archiv : European journal of physiology·Michelle Boone, Peter M T Deen
Jun 24, 2008·Pflügers Archiv : European journal of physiology·Wolfgang NeuhoferFranz-X Beck
Jul 9, 2009·Pflügers Archiv : European journal of physiology·Min Seong KwonH Moo Kwon
Jul 21, 2011·Pflügers Archiv : European journal of physiology·Markus M RinschenBayram Edemir
Nov 28, 2012·Cellular and Molecular Neurobiology·Min-Hee YiDong Woon Kim
Feb 5, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ming-Jiun YuMark A Knepper
Jun 27, 2008·The Journal of Biological Chemistry·Min Seong KwonH Moo Kwon
Aug 6, 2010·Molecular Biology of the Cell·Isabelle RothUdo Hasler
Nov 8, 2012·Veterinary Clinical Pathology·M Judith RadinMark A Knepper
Dec 10, 2009·Physiological Genomics·Dmitry TchapyjnikovMark A Knepper
Oct 25, 2007·Physiological Genomics·Panapat UawithyaMark A Knepper
May 14, 2009·The Journal of Clinical Investigation·Songcang ChenDavid G Gardner
Apr 13, 2007·Journal of the American Society of Nephrology : JASN·Doyeob KimGregory R Dressler
Nov 23, 2007·Journal of the American Society of Nephrology : JASN·Mauro BustamanteEric Féraille
Dec 22, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Yong Pyo LeeHo Sub Lee
Aug 16, 2008·The Journal of Biological Chemistry·Udo HaslerEric Féraille
Apr 16, 2013·Clinical and Experimental Nephrology·Justin L L WilsonMark A Knepper
Oct 26, 2013·Basic Research in Cardiology·Arkady RutkovskiyJarle Vaage
Sep 25, 2008·Kidney International·Elena A ZalyapinDennis A Ausiello
Oct 20, 2012·Molecular Aspects of Medicine·Sei Sasaki
Dec 5, 2008·Kidney International·Mee R SheenH Moo Kwon
Jun 4, 2008·Seminars in Nephrology·Richard BouleyDennis Brown
Apr 27, 2013·Journal of Molecular Signaling·Chris Yk Cheung, Ben Cb Ko
Jun 3, 2008·Experimental Physiology·Takako SaitoSan-e Ishikawa
Oct 7, 2015·Frontiers in Physiology·Christoph KüperWolfgang Neuhofer
Aug 25, 2015·Biochemical and Biophysical Research Communications·Kai Guo, Faguang Jin
Jan 21, 2015·Frontiers in Physiology·Christoph KüperWolfgang Neuhofer
Oct 5, 2017·Proceedings of the National Academy of Sciences of the United States of America·Kiyoshi IsobeMark A Knepper
Mar 17, 2017·American Journal of Physiology. Renal Physiology·Jacqueline R HwangHyun Jun Jung
Jan 6, 2017·American Journal of Physiology. Renal Physiology·Wen SuXiao-Yan Zhang
Jan 10, 2019·American Journal of Physiology. Renal Physiology·Jayalakshmi LakshmipathiDonald E Kohan
Mar 25, 2018·Journal of the American Society of Nephrology : JASN·Hyun Jun JungMark A Knepper
Nov 1, 2018·Journal of Cellular Physiology·Shadia BeainiNassim Fares
Dec 15, 2006·American Journal of Physiology. Cell Physiology·Song-Zhe LiFeng Chen

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