PMID: 15402704Jan 20, 1950Paper

Tonicity-volume relations in partially hemolyzed hypotonic systems

The Journal of General Physiology
E PONDER

Abstract

The linear relation between the red cell volume V and the reciprocal of the tonicity T of a hypotonic medium is not the linear one expected on the basis of the van't Hoff-Mariotte law, particularly when a fraction p of the cells are hemolyzed and the volume V/(1 - p) of the (1 - p) cells which remain intact is considered. In systems of relatively high tonicity in which p is zero, the relation is linear but its slope is usually too small; at lower tonicities in which p has a value between zero and 0.35, the volumes are larger than those expected on the basis of the van't Hoff-Mariotte law, while at still smaller tonicities they are much smaller than expected. The volume measurements referred to are made with a high speed hematocrit; the results obtained in systems containing relatively high and relatively low volume concentrations of cells are contrasted with each other, and allowance is made in the calculations for the volume of the hypotonic medium surrounding the cells being limited. Attempts are made at an explanation of the anomalous results in terms of incomplete packing, of a stepwise as opposed to an all-or-none loss of Hb from the cells, of a heterogeneity in the swelling properties of the cells of the population, of a ...Continue Reading

References

May 1, 1942·The Journal of Clinical Investigation·G M Guest, M Wing

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Citations

May 1, 1951·The Journal of General Physiology·E PONDER
May 1, 1952·The Journal of General Physiology·T TEORELL
Feb 18, 1958·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·D A DICK, L M LOWENSTEIN

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