Tonsil-derived mesenchymal progenitor cells acquire a follicular dendritic cell phenotype under cytokine stimulation

Cytokine
Kyung-Ah ChoSo-Youn Woo

Abstract

Tonsils comprise part of the mucosal immune system and contain lymphocytes, macrophages, and follicular dendritic cells (FDCs). FDCs are located in the B cell area of the follicles of secondary lymphoid organs, such as the spleen, tonsils, or lymph nodes, and they trap and retain immune complexes on their surfaces to regulate B cell activation and maturation. Stromal cells from the palatine tonsils are often used for FDC in vitro studies, and it has been reported that human palatine tonsils may be a good source of multipotent mesenchymal cells. Therefore, we assessed whether tonsil-derived mesenchymal stromal cells could differentiate into a FDC-like phenotype. We discovered that stromal cells isolated from human tonsils not only had the potential to differentiate into various cell types of mesenchymal origin, but they also could differentiate into FDC-like cells under cytokine stimulation in vitro.

References

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Aug 7, 2002·Seminars in Immunology·Kirsten van Nierop, Cornelis de Groot
May 26, 2009·Journal of Applied Oral Science : Revista FOB·Ricardo Alves MesquitaSuzana Cantanhede Orsini Machado de Souza
Jun 15, 2011·Nature Immunology·Javier Rangel-MorenoTroy D Randall

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Citations

Nov 10, 2015·Biomacromolecules·Du Young KoByeongmoon Jeong
Jun 24, 2014·Experimental Cell Research·Kyung-Ha RyuJoo-Won Park
Feb 28, 2017·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Eun Mi SongKi Nam Shim
Jun 19, 2015·American Journal of Rhinology & Allergy·Ramachandran SamivelJi-Hun Mo
Aug 11, 2017·Muscle & Nerve·Saeyoung ParkSung-Chul Jung
Sep 17, 2019·World Journal of Stem Cells·Kyung-Ah ChoHan Su Kim

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