Too many strictures on structure

Trends in Microbiology
Kevin D Young

Abstract

In a recent Opinion article in Trends in Microbiology, Dmitriev et al. proposed an alternative to the existing model of peptidoglycan structure, in which the cell wall is composed of chains that are perpendicular to the membrane (as opposed to horizontal) and form a scaffold interconnected by peptide branches. However, both this model and the classical model are based on underlying assumptions about pore sizes, composition and structural regularity that deserve careful consideration. Not only do the uncertainties surrounding these basic mechanical questions make it impossible to decide which model of peptidoglycan structure is correct, they also leave open the possibility that the real structure is an amalgam of these or other models that have yet to be described.

References

Sep 27, 2000·Journal of Bacteriology·D PinkT Beveridge
May 20, 2003·Journal of Bacteriology·Boris A DmitrievStefan Ehlers
Sep 3, 2004·Journal of Bacteriology·Waldemar Vollmer, Joachim-Volker Höltje
Jul 14, 2005·Biopolymers·Marit Sletmoen, Bjørn T Stokke
Oct 21, 2005·Trends in Microbiology·Boris DmitrievStefan Ehlers

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Citations

Oct 7, 2008·Journal of the American Chemical Society·Tsung-Shing Andrew WangDaniel Kahne
Jun 19, 2012·Molecular Membrane Biology·Phillip E KlebbaSalete M Newton
Jan 16, 2008·FEMS Microbiology Reviews·Waldemar VollmerMiguel A de Pedro
Mar 4, 2014·PLoS Computational Biology·James C GumbartBenoît Roux
Jun 8, 2010·Journal of Medicinal Chemistry·Jed F Fisher, Shahriar Mobashery

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Related Concepts

Related Feeds

Bacterial Cell Wall Structure (ASM)

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Bacterial Cell Wall Structure

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

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