Too Much Tau in Interneurons Impairs Adult Hippocampal Neurogenesis in Alzheimer's Disease.

Cell Stem Cell
Ramsey NajmYadong Huang

Abstract

Understanding why adult hippocampal neurogenesis (AHN) is impaired in Alzheimer's disease (AD) is essential for unravelling its role in pathogenesis. In this issue of Cell Stem Cell, Zheng et al. (2020) report that human tau accumulation in dentate gyrus GABAergic interneurons disrupts AHN and strengthening GABAergic signaling restores AHN and improves cognition in an AD mouse model.

References

Oct 15, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yaisa Andrews-ZwillingYadong Huang
Mar 20, 2012·Cell·Yadong Huang, Lennart Mucke
Nov 5, 2016·Cell·J Tiago GonçalvesFred H Gage
Jan 28, 2017·Molecular Therapy : the Journal of the American Society of Gene Therapy·Xiaoguang LiJian-Zhi Wang
Jun 13, 2019·Molecular Neurodegeneration·Ramsey NajmYadong Huang

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