Too Much, Too Little or Just Enough: A Goldilocks Effect for IL-13 and Skin Barrier Regulation?

The Journal of Investigative Dermatology
Jessica StridAlan D Irvine

Abstract

The mechanistic relationship between IL-4/IL-13 and skin barrier function has been of interest since the filaggrin discovery and the subsequent in vitro demonstration that IL-4 and IL-13 downregulate filaggrin expression in cultured keratinocytes. Hönzke and colleagues explore these interactions further. The effects of IL-4/ll-13 may be context dependent, with differing roles in homeostasis and in disease.

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Citations

Oct 6, 2016·The Journal of Allergy and Clinical Immunology·David A EwaldEmma Guttman-Yassky
May 28, 2019·Frontiers in Cell and Developmental Biology·Oindrila BhattacharjeeSrikala Raghavan
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Oct 10, 2021·Nature Communications·Esther HosteGeert van Loo

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