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Too packed to change: site-specific substitution rates and side-chain packing in protein evolution

bioRxiv

Dec 30, 2014

María Laura Marcos, Julian Echave

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Abstract

In protein evolution, due to functional and biophysical constraints, the rates of amino acid substitution differ from site to site. Among the best predictors of site-specific rates is packing density. The packing density measure that best correlates with rates is the weighted contact nu...read more

Mentioned in this Paper

Enzymes, antithrombotic
Contact-Sensitizing Agents
Amino Acid Substitution
Biophysics
Enzymes, peripheral vasodilators
Chemical Substitution
Packing Dosage Form
Enzymes, hematological
Cocaine
Side
8
4
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  • Too packed to change: site-specific substitution rates and side-chain packing in protein evolution

    bioRxiv

    Dec 30, 2014

    María Laura Marcos, Julian Echave

    PMID: 990013359

    DOI: 10.1101/013359

    Abstract

    In protein evolution, due to functional and biophysical constraints, the rates of amino acid substitution differ from site to site. Among the best predictors of site-specific rates is packing density. The packing density measure that best correlates with rates is the weighted contact nu...read more

    Mentioned in this Paper

    Enzymes, antithrombotic
    Contact-Sensitizing Agents
    Amino Acid Substitution
    Biophysics
    Enzymes, peripheral vasodilators
    8
    4

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