Too sweet: Problems of protein glycation in the eye.

Experimental Eye Research
Eloy Bejarano, Allen Taylor

Abstract

Laboratory and epidemiological data indicate that high blood sugar levels and/or consuming high glycemia diets are linked to multiple age-related diseases, including age-related macular degeneration, cataract, Parkinson's disease, Alzheimer's disease, diabetic retinopathy, and, apparently glaucoma. High concentrations of blood sugar and perturbations of the systems that regulate blood sugar lead to the accumulation of advanced-glycation end products (AGEs). AGEs are toxic compounds that are formed from the combination of sugars and their metabolites with biomolecules in a non-enzymatic biochemical reaction called glycation. In vitro and in vivo data indicate that high sugar consumption is associated with accumulation of AGEs in a variety of human tissues. Hyperglycemia, along with an oxidative environment and limited cell proliferation in many ocular tissues, encourages formation and precludes dilution of AGEs and associated damage by cell division. These circumstances make many eye tissues vulnerable to glycation-derived damage. Here, we summarize research regarding glycation-induced ocular tissue dysfunction and its contribution to the onset and development of eye disorders. We also discuss how management of carbohydrate nutr...Continue Reading

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Citations

Apr 10, 2019·Oxidative Medicine and Cellular Longevity·Nidhi MahajanRajat Sandhir
Sep 24, 2020·Nutrients·Sarah G FranciscoSheldon Rowan
Nov 5, 2020·Antioxidants·Gemma AragonèsEloy Bejarano
Jan 26, 2020·Archivos de la Sociedad Española de Oftalmología·S M Sanz-GonzálezM D Pinazo-Durán
Mar 11, 2020·Progress in Retinal and Eye Research·J Sebag
May 8, 2020·International Journal of Biological Macromolecules·Ejlal Mohamed AbdullahAjamaluddin Malik
Sep 22, 2020·International Journal of Biological Macromolecules·Anna FerozBilqees Bano
May 1, 2021·International Journal of Molecular Sciences·Sander De BruyneJoris R Delanghe
Jul 17, 2021·Neural Regeneration Research·Allen Taylor, Eloy Bejarano
Aug 21, 2021·Investigative Ophthalmology & Visual Science·Jingxin HeZhijie Li
Dec 5, 2021·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Mijie LiSeang-Mei Saw

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