Tools of the trade: investigations into design strategies of small molecules to target components in Alzheimer's disease

Chembiochem : a European Journal of Chemical Biology
Jeffrey S Derrick, Mi Hee Lim

Abstract

The growing prevalence of Alzheimer's disease (AD) has warranted the development of effective therapeutic methods. Current available drugs for AD (i.e., acetylcholinesterase (AChE) inhibitors and N-methyl-D-aspartate (NMDA) receptor antagonists) have only offered brief symptomatic relief. Considering that the numbers affected by AD are projected to substantially rise, long-term strategies are urgently needed. The multiple series of small molecules to combat AD have been expanded, with current methods taking aim at factors, such as misfolded protein accumulation, metal ion dyshomeostasis, and oxidative stress. This concept article focuses on describing the design of compounds to target various components of AD and underlining recent advances that have been made.

References

Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·A Lorenzo, B A Yankner
Jul 17, 1998·Journal of the Neurological Sciences·M A LovellW R Markesbery
Mar 13, 1999·Chemistry & Biology·L A Amos, J Löwe
Feb 1, 2000·Drug Discovery Today·D E Clark, S D Pickett
Mar 10, 2004·Bioorganic & Medicinal Chemistry Letters·Tooru KimuraYoshiaki Kiso
Sep 18, 2004·The Journal of Pharmacology and Experimental Therapeutics·M L MichaelisG I Georg
Aug 10, 2005·Proceedings of the National Academy of Sciences of the United States of America·Trent NguyenStephen M Massa
Oct 6, 2005·British Journal of Pharmacology·Alessandra Gaeta, Robert C Hider
Feb 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jian-Ping GuoPatrick L McGeer
Jun 29, 2006·Cellular and Molecular Life Sciences : CMLS·T HamaguchiM Yamada
May 15, 2007·Biochemical and Biophysical Research Communications·Xiao-Yang SuYan-Mei Li
Oct 9, 2007·Peptides·Lian-Xiu ZhouYan-Mei Li
Dec 28, 2007·The International Journal of Biochemistry & Cell Biology·Gulay FilizAnthony R White
Feb 29, 2008·Dalton Transactions : an International Journal of Inorganic Chemistry·Arvi Rauk
Apr 23, 2008·Chemical Reviews·Emily L QueChristopher J Chang
May 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Kevin J BarnhamRoberto Cappai
Jun 27, 2008·Proceedings of the National Academy of Sciences of the United States of America·Wei-Feng XueSheena E Radford
Jul 16, 2008·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ashley I Bush, Rudolph E Tanzi
Aug 2, 2008·Lancet Neurology·Norman R Relkin
Aug 30, 2008·The Journal of Biological Chemistry·Wei-hui WuYan-mei Li
Sep 23, 2008·Biochemistry·Alice SoragniMarkus Zweckstetter
Oct 16, 2008·Current Medicinal Chemistry·D Muñoz-Torrero
Jan 23, 2009·Journal of Alzheimer's Disease : JAD·Han-Chang Huang, Zhao-Feng Jiang
Jan 30, 2009·Medicinal Research Reviews·Silvia BologninPaolo Zatta
Mar 31, 2009·Angewandte Chemie·Roland Jakob-Roetne, Helmut Jacobsen
Jun 23, 2009·Journal of Alzheimer's Disease : JAD·Akihiko Takashima
Aug 20, 2009·Chemical Society Reviews·Arvi Rauk
Sep 1, 2009·Experimental Neurology·Todd E GoldeJada Lewis
Oct 13, 2009·Inorganic Chemistry·Allana M MancinoMi Hee Lim

❮ Previous
Next ❯

Citations

Apr 16, 2016·Future Medicinal Chemistry·Michela RosiniAnna Minarini
May 3, 2016·Journal of Inorganic Biochemistry·Michael R JonesTim Storr
Oct 7, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Amandine Conte-DabanChristelle Hureau
Jan 19, 2017·Journal of the American Chemical Society·Jeffrey S DerrickMi Hee Lim
Jan 16, 2018·Chemistry : a European Journal·Amandine Conte-DabanChristelle Hureau
Jul 27, 2018·Metallomics : Integrated Biometal Science·Hyuck Jin LeeMi Hee Lim
Mar 17, 2018·Biochemistry. Biokhimii︠a︡·O V GalzitskayaO M Selivanova
Nov 24, 2020·BioMed Research International·Namdoo Kim, Hyuck Jin Lee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.