Tools of the trade: psychophysiological interactions and functional connectivity.

Social Cognitive and Affective Neuroscience
Jill X O'ReillyHeidi Johansen-Berg

Abstract

Psychophysiological interactions (PPIs) analysis is a method for investigating task-specific changes in the relationship between activity in different brain areas, using functional magnetic resonance imaging (fMRI) data. Specifically, PPI analyses identify voxels in which activity is more related to activity in a seed region of interest (seed ROI) in a given psychological context, such as during attention or in the presence of emotive stimuli. In this tutorial, we aim to give a simple conceptual explanation of how PPI analysis works, in order to assist readers in planning and interpreting their own PPI experiments.

Associated Clinical Trials

References

Oct 1, 1969·British Journal of Pharmacology·S A Turkanis
Oct 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B BiswalJ S Hyde
Nov 5, 1997·NeuroImage·K J FristonR J Dolan
Sep 2, 2003·NeuroImage·K J FristonW Penny
Dec 14, 2004·Nature Neuroscience·Andreas HeinzChristian Büchel
Dec 22, 2004·Journal of Anatomy·Klaas Enno Stephan
May 12, 2005·Schizophrenia Research·Kristine BoksmanRichard W J Neufeld
Sep 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·J S DamoiseauxC F Beckmann
Feb 7, 2008·IEEE Transactions on Neural Networks·A Hyvärinen
Apr 12, 2008·Cerebral Cortex·Michael D GreiciusRobert F Dougherty
Feb 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·C J HoneyP Hagmann
Feb 5, 2009·Nature Reviews. Neuroscience·Ed Bullmore, Olaf Sporns
Jul 22, 2009·Proceedings of the National Academy of Sciences of the United States of America·Stephen M SmithChristian F Beckmann
Dec 21, 2010·Nature Reviews. Neuroscience·Gustavo DecoAnthony R McIntosh
Jan 22, 2011·Annals of the New York Academy of Sciences·John T Cacioppo, Jean Decety
Feb 11, 2012·Proceedings of the National Academy of Sciences of the United States of America·Stephen M SmithKamil Ugurbil
Jan 1, 2011·Brain Connectivity·Karl J Friston

❮ Previous
Next ❯

Citations

Jul 31, 2013·Nature Neuroscience·Michael W ColeTodd S Braver
May 28, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Eric D ClausKent E Hutchison
Oct 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Dan-Mikael EllingsenSiri Leknes
Sep 4, 2013·Hormones and Behavior·Eduard T KlapwijkSarah-Jayne Blakemore
Oct 2, 2012·NeuroImage·Helen Blank, Katharina von Kriegstein
Jan 15, 2014·Brain and Cognition·Kati L HealeyErika E Forbes
Oct 13, 2014·Nature Neuroscience·Laurence T HuntTimothy E J Behrens
Jul 8, 2014·Journal of Cognitive Neuroscience·Martha M ShiellRobert J Zatorre
Feb 5, 2014·Social Cognitive and Affective Neuroscience·David V SmithScott A Huettel
Sep 12, 2013·Trends in Cognitive Sciences·Luca CocchiJason B Mattingley
Feb 14, 2016·Cerebral Cortex·Aaron KucyiEve M Valera
Mar 13, 2014·Molecular Pain·Albert LeungTony Yaksh
Apr 29, 2015·Journal of Clinical Child and Adolescent Psychology : the Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53·Judith K MorganErika E Forbes
Feb 13, 2015·Proceedings of the National Academy of Sciences of the United States of America·Meghan H PugliaJessica J Connelly
Nov 14, 2015·Cerebral Cortex·Valerie BonnelleMasud Husain
Sep 25, 2014·Cerebral Cortex·V A van AstT D Wager
Feb 18, 2016·BioMed Research International·Becky WongBeth O'Brien
Mar 2, 2016·Journal of Psychiatric Research·Anna LorenzenAlexander Prehn-Kristensen
Aug 8, 2015·Social Cognitive and Affective Neuroscience·Martin Korsbak MadsenPatrick MacDonald Fisher
Mar 12, 2015·Brain Imaging and Behavior·Macià Buades-RotgerUlrike M Krämer
Jul 19, 2015·Behavioural Brain Research·Erhan GençOnur Güntürkün
Feb 3, 2016·Social Cognitive and Affective Neuroscience·Tal GonenTalma Hendler
Nov 28, 2014·Autism Research : Official Journal of the International Society for Autism Research·Jacqueline FitzgeraldJane McGrath
Nov 8, 2014·Autism Research : Official Journal of the International Society for Autism Research·Megha ShardaNandini C Singh
Jun 23, 2015·Human Brain Mapping·James P TrujilloYsbrand D van der Werf
May 13, 2015·Social Cognitive and Affective Neuroscience·Sebastian KorbDidier Grandjean
Dec 2, 2015·Nature Communications·Lara J PierceDenise Klein
Nov 27, 2015·Neurobiology of Learning and Memory·Margaret L Schlichting, Alison R Preston
Feb 11, 2015·Human Brain Mapping·Magali ComteEric Fakra
Aug 6, 2015·Journal of Cognitive Neuroscience·Louise KauffmannCarole Peyrin
Jul 24, 2013·Alcoholism, Clinical and Experimental Research·Lara A RayDara G Ghahremani
Mar 19, 2016·Human Brain Mapping·Christiane S RohrHadas Okon-Singer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Nico U F DosenbachSteven E Petersen
Proceedings of the National Academy of Sciences of the United States of America
Marcus E RaichleG L Shulman
© 2021 Meta ULC. All rights reserved