Tooth Formation: Are the Hardest Tissues of Human Body Hard to Regenerate?

International Journal of Molecular Sciences
Juliana BaranovaEdda Tobiasch

Abstract

With increasing life expectancy, demands for dental tissue and whole-tooth regeneration are becoming more significant. Despite great progress in medicine, including regenerative therapies, the complex structure of dental tissues introduces several challenges to the field of regenerative dentistry. Interdisciplinary efforts from cellular biologists, material scientists, and clinical odontologists are being made to establish strategies and find the solutions for dental tissue regeneration and/or whole-tooth regeneration. In recent years, many significant discoveries were done regarding signaling pathways and factors shaping calcified tissue genesis, including those of tooth. Novel biocompatible scaffolds and polymer-based drug release systems are under development and may soon result in clinically applicable biomaterials with the potential to modulate signaling cascades involved in dental tissue genesis and regeneration. Approaches for whole-tooth regeneration utilizing adult stem cells, induced pluripotent stem cells, or tooth germ cells transplantation are emerging as promising alternatives to overcome existing in vitro tissue generation hurdles. In this interdisciplinary review, most recent advances in cellular signaling guidi...Continue Reading

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Citations

Aug 30, 2020·International Journal of Molecular Sciences·Anna Labedz-MaslowskaEwa Zuba-Surma
May 26, 2021·Journal of Oral Biosciences·Han Ngoc MaiHan-Sung Jung
Jun 3, 2021·Materials·Mihaela OlaruGabriela Calin
Apr 28, 2021·Integrative and Comparative Biology·John ShaheenJohn Abramyan
Jul 3, 2021·International Journal of Molecular Sciences·Sarah Hani ShoushrahEdda Tobiasch
Jul 25, 2021·Cell and Tissue Research·Eun-Jung KimHan-Sung Jung
Oct 13, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Min LiLijuan Guo
Nov 2, 2021·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Chuanqing MaoWeihui Chen

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Methods Mentioned

BETA
X-ray

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