Tooth patterning and enamel formation can be manipulated by misexpression of TNF receptor Edar

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Johanna PispaIrma Thesleff

Abstract

Signaling by Edar, a tumor necrosis factor receptor, is required for the development of ectodermal organs. Mutations in Edar or other molecules of the same signaling pathway cause ectodermal dysplasias in humans and mice. In these diseases, teeth are missing or malformed, and the development of hairs and several glands is hypoplastic. During tooth and hair development, Edar expression becomes patterned to ectodermal placodes and signaling centers. This localization has been suggested to be required for organogenesis. We have expressed Edar throughout the ectoderm using the keratin 14 promoter and show that this misexpression disrupts tooth patterning and differentiation. Tooth shape and cusp number are differentially affected, depending on the amount of transgene expression. In addition, tooth enamel formation is defective in a dose-dependent manner. We speculate that the tooth patterning defects are caused by ectopic Edar activity outside the signaling centers.

References

Feb 1, 1994·Archives of Oral Biology·J J Damen, J M ten Cate
Jan 7, 1997·Proceedings of the National Academy of Sciences of the United States of America·X WangE Fuchs
Jan 22, 2000·Developmental Biology·J PispaI Thesleff
Mar 8, 2000·Mechanisms of Development·J Jernvall, I Thesleff
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·J JernvallI Thesleff
Sep 26, 2001·Experimental Cell Research·P KoppinenM L Mikkola
May 9, 2002·Science's STKE : Signal Transduction Knowledge Environment·Irma Thesleff, Marja L Mikkola
Jun 1, 2002·Gene·Meredith C DurmowiczDavid Schlessinger
Jun 6, 2002·Proceedings of the National Academy of Sciences of the United States of America·Isaac Salazar-Ciudad, Jukka Jernvall
Jun 19, 2003·Developmental Biology·Tuija MustonenIrma Thesleff

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Citations

Jun 1, 2012·Journal of Human Genetics·Jeong-Heuy ParkRyosuke Kimura
Nov 13, 2004·Nature·Aapo T KangasJukka Jernvall
Aug 17, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jan ProchazkaRenata Peterkova
Aug 13, 2011·Breast Cancer Research : BCR·Olivia WansburyBeatrice A Howard
Dec 15, 2010·International Journal of Biological Sciences·Zhengguo CaoJian Q Feng
Mar 22, 2014·Journal of Molecular Histology·Bingmei WangYanding Zhang
May 15, 2008·Expert Opinion on Biological Therapy·Etsuko Ikeda, Takashi Tsuji
Jul 27, 2011·Biochemical Pharmacology·Alessandro RufiniGerry Melino
Oct 16, 2015·European Journal of Oral Sciences·Ye TianXiaofang Wang
Aug 15, 2009·American Journal of Medical Genetics. Part a·Marja L Mikkola
Sep 6, 2008·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·P J De CosterA Huysseune
Feb 26, 2011·International Journal of Paediatric Dentistry·Hai-Hua LeiLi-Hong Ge
Feb 11, 2011·Genesis : the Journal of Genetics and Development·Xiu-Ping Wang, Jiabing Fan
Jul 15, 2015·Histochemistry and Cell Biology·Sanjiv NeupaneJae-Young Kim
Oct 31, 2009·Current Opinion in Genetics & Development·Marianna Bei
Oct 7, 2009·American Journal of Human Genetics·Ryosuke KimuraHiroki Oota
Aug 16, 2016·PloS One·Yumiko TogoKazuhisa Bessho
Mar 28, 2018·Scientific Reports·Kazuyuki SaitoKazuhisa Bessho
Jan 20, 2019·Development·Elena M PopaAbigail S Tucker
Mar 9, 2012·Nature·Enni HarjunmaaJukka Jernvall
Aug 8, 2020·Integrative and Comparative Biology·Alexa SadierKaren E Sears

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