Tooth survival and periodontal tissues healing of allogenic-transplanted teeth in the mice

Oral Diseases
E KimH S Jung

Abstract

For the successful organ transplantation, immune rejection has to be considered. Autogenic transplantation of human teeth is generally carried out free of clinical difficulty because of the lack of immune reaction, whereas allogenic tooth transplantations easily induce host immune rejection to donor tissues. The aim of the present study was to evaluate the replacement of donor tissue by host cells after allogenic tooth transplantation. First molars extracted from lacZ transgenic ROSA26 mice were transplanted into the alveolar socket and the tongue of host wildtype mice, where the first molar had existed. Donor cells from lacZ transgenic mice were not detected in the periodontal ligament space, but rather in the pulp chamber of the donor tooth. Furthermore, if the pulp chamber was widely open to an affluent blood supply, odontoblasts and fibroblasts in the donor tissue survived in the dental pulp. Our experimental models using lacZ transgenic ROSA26 mice clearly demonstrate that donor periodontal tissue cells are replaced by host cells and that periodontal tissue can regenerate after allogenic tooth transplantation. Furthermore, our models suggest that donor pulpal cells can survive if the vascular supply into the pulp chamber i...Continue Reading

References

Apr 1, 1978·Journal of Oral Pathology·M E Atkinson
Jan 1, 1978·Oral Surgery, Oral Medicine, and Oral Pathology·A SkoglundK Wallenius
Jun 1, 1987·International Journal of Oral and Maxillofacial Surgery·O SchwartzB Klausen
Aug 1, 1988·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·O Schwartz, J O Andreasen
Apr 1, 1985·International Journal of Oral Surgery·L Kristerson
Oct 1, 1974·American Journal of Orthodontics·O Slagsvold, B Bjercke
Dec 1, 1972·Transplantation·P J Robinson, D T Rowlands
May 1, 1968·Journal of Dental Research·C FongM Morris
Aug 1, 1984·International Journal of Oral Surgery·L Kristerson, J O Andreasen
Jan 1, 1982·Leukemia Research·A Hirt, H P Wagner
Jul 1, 1994·Journal of Periodontal Research·G Nethander
Mar 1, 1993·Clinical Oral Implants Research·S SchouK S Kornman
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·B P ZambrowiczP Soriano
Nov 23, 2000·Proceedings of the National Academy of Sciences of the United States of America·S GronthosS Shi
Apr 5, 2001·Nature·D OrlicP Anversa
Aug 14, 2001·Dental Traumatology : Official Publication of International Association for Dental Traumatology·S J LeeK Y Kum
Sep 28, 2002·Journal of Dental Research·C S YoungP C Yelick
Nov 13, 2002·Dental Traumatology : Official Publication of International Association for Dental Traumatology·O Schwartz, J O Andreasen
Nov 22, 2002·Dental Traumatology : Official Publication of International Association for Dental Traumatology·O SchwartzJ O Andreasen
Mar 6, 2003·Microscopy Research and Technique·Yang Chai, Harold C Slavkin
Mar 6, 2003·Microscopy Research and Technique·Masaki ShimonoTakashi Inoue
Apr 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Masako MiuraSongtao Shi
Jun 26, 2004·Journal of Dental Research·A OhazamaP T Sharpe
Jun 15, 2005·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Euiseong KimSeung-Jong Lee

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Citations

Jul 6, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Rahul KumarEkta Priya
Sep 4, 2008·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Yasuhiko TakamoriHayato Ohshima
May 11, 2010·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Quanmei YanXing Long
Nov 23, 2007·Bone·Akihiro HosoyaHiroaki Nakamura
Jan 23, 2009·Journal of Cellular Physiology·Naohisa WadaStan Gronthos
Feb 20, 2009·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Hideki UnnoHayato Ohshima
Apr 24, 2012·Dental Traumatology : Official Publication of International Association for Dental Traumatology·Tanida SrisuwanErik W Thompson
Apr 11, 2015·Stem Cells International·Wenjun Zhu, Min Liang

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