Top-down activation of fusiform cortex without seeing faces in prosopagnosia

Cerebral Cortex
Ruthger RighartPatrik Vuilleumier

Abstract

Face processing can be modified by bottom-up and top-down influences, but it is unknown how these processes interact in patients with face-recognition impairments (prosopagnosia). We investigated a prosopagnosic with lesions in right occipital and left fusiform cortex but whose right fusiform gyrus is intact and still activated during face-processing tasks. P.S., a patient with a well-established and selective agnosia for faces, was instructed to detect the presence of either faces or houses in pictures with different amounts of noise. The right fusiform face area (FFA) showed reduced responses to face information when visual images were degraded with noise. However, her right FFA still activated to noise-only images when she was instructed to detect faces. These results reveal that fusiform activation is still selectively modulated by task demands related to the anticipation of a face, despite severe face-recognition deficits and the fact that no reliable stimulus-driven response is evoked by actual facial information. Healthy controls showed stimulus-driven responses to faces in fusiform, and in right but not left occipital cortex, suggesting that the latter area alone might provide insufficient facial information in P.S. The...Continue Reading

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Citations

Jul 9, 2010·Journal of the International Neuropsychological Society : JINS·Richard E FryeSusan Landry
Sep 7, 2011·Cerebral Cortex·Markus GschwindPatrik Vuilleumier
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Dec 14, 2018·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Xiaoqing GaoBruno Rossion

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