Top-Down Inhibitory Mechanisms Underlying Auditory-Motor Integration for Voice Control: Evidence by TMS.

Cerebral Cortex
Dongxu LiuHanjun Liu

Abstract

The dorsolateral prefrontal cortex (DLPFC) has been implicated in auditory-motor integration for accurate control of vocal production, but its precise role in this feedback-based process remains largely unknown. To this end, the present event-related potential study applied a transcranial magnetic stimulation (TMS) protocol, continuous theta-burst stimulation (c-TBS), to disrupt cortical activity in the left DLPFC as young adults vocalized vowel sounds while hearing their voice unexpectedly shifted upwards in pitch. The results showed that, as compared to the sham condition, c-TBS over left DLPFC led to significantly larger vocal compensations for pitch perturbations that were accompanied by significantly smaller cortical P2 responses. Source localization analyses revealed that this brain activity pattern was the result of reduced activation in the left superior frontal gyrus and right inferior parietal lobule (supramarginal gyrus). These findings demonstrate c-TBS-induced modulatory effects of DLPFC on the neurobehavioral processing of vocal pitch regulation, suggesting that disrupting prefrontal function may impair top-down inhibitory control mechanisms that prevent speech production from being excessively influenced by audit...Continue Reading

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Citations

Mar 23, 2021·Journal of Voice : Official Journal of the Voice Foundation·Razieh AlemiMickael L D Deroche
Jun 4, 2021·Frontiers in Human Neuroscience·Ingo HertrichHermann Ackermann

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