Top quality blastocyst formation rates in relation to progesterone levels on the day of oocyte maturation in GnRH antagonist IVF/ICSI cycles

PloS One
V S VanniEnrico Papaleo

Abstract

Cycles with progesterone elevation during controlled ovarian stimulation (COS) for IVF/ICSI are commonly managed with a "freeze-all" strategy, due to a well-recognized detrimental effect of high progesterone levels on endometrial receptivity. However, also a detrimental effect of elevated progesterone on day-3 embryo quality has recently been found with regards to top quality embryo formation rate. Because blastocyst culture and cryopreservation are largely adopted, we deemed relevant to determine whether this detrimental effect is also seen on blastocyst quality on day 5-6. This issue was investigated through a large two-center retrospective study including 986 GnRH antagonist IVF/ICSI cycles and using top quality blastocyst formation rate as the main outcome. Results showed that on multivariate analysis sperm motility (p<0.01) and progesterone levels at ovulation triggering (p = 0.01) were the only two variables that significantly predicted top quality blastocyst formation rate after adjusting for relevant factors including female age, BMI, basal AMH and total dose of FSH used for COS. More specifically, progesterone levels at induction showed an inverse relation with top quality blastocyst formation (correlation coefficient ...Continue Reading

References

Jul 23, 2008·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Foad AzemAmi Amit
Mar 20, 2009·Fertility and Sterility·Bruce S ShapiroShyni Thomas
Apr 20, 2011·Human Reproduction·UNKNOWN Alpha Scientists in Reproductive Medicine and ESHRE Special Interest Group of Embryology
Feb 9, 2012·Systems Biology in Reproductive Medicine·Lynne C O'SheaTrudee Fair
Mar 2, 2012·Reproductive Biomedicine Online·M Al-AzemiH M Fatemi
Aug 1, 2012·Reproduction in Domestic Animals = Zuchthygiene·T Fair, P Lonergan
Jul 11, 2014·Human Reproduction·Anna Pia Ferraretti, Luca Gianaroli
Sep 28, 2014·Journal of Assisted Reproduction and Genetics·Liliana RestelliEnrico Papaleo
Jun 11, 2016·Reproductive Biomedicine Online·Giulia IntraPaola Viganò
Dec 14, 2016·BioMed Research International·Sara CalicchiaBruno Papaleo

❮ Previous
Next ❯

Citations

Apr 18, 2018·Current Opinion in Obstetrics & Gynecology·Biljana Popovic-TodorovicChristophe Blockeel
Jun 13, 2018·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Barbara LawrenzHuman Fatemi
Jan 28, 2018·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Leonti GrinShevach Friedler
Jan 3, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Cynthia SimonRoger Leandri
May 8, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Francisca MartínezBuenaventura Coroleu
May 14, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Francisca MartínezNikolaos Polyzos
Dec 24, 2019·Human Reproduction Update·Yossi MizrachiAriel Weissman
Jul 3, 2020·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Fazilet Kubra BoynukalinMustafa Bahceci
May 17, 2018·Hormone Molecular Biology and Clinical Investigation·Charalampos SiristatidisGeorge Daskalakis
Feb 26, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Yavuz Emre ŞükürMurat Sönmezer
Jan 25, 2020·Seminars in Reproductive Medicine·Gurkan BozdagHakan Yarali
Jul 28, 2018·Journal of Assisted Reproduction and Genetics·Apostolos KaponisGeorge Decavalas
Mar 21, 2021·Human Reproduction Update·Francisca MartinezNikolaos P Polyzos
Mar 20, 2021·Journal of Gynecology Obstetrics and Human Reproduction·Khadijeh PouyaRuşen Aytaç
May 20, 2021·Journal of Assisted Reproduction and Genetics·Maria Luisa PardiñasMaria José De Los Santos

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Software Mentioned

Statistical Package for Social Sciences ( SPSS )

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.