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TopHat: discovering splice junctions with RNA-Seq

Bioinformatics

May 1, 2009

Cole TrapnellSteven L. Salzberg

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Abstract

A new protocol for sequencing the messenger RNA in a cell, known as RNA-Seq, generates millions of short sequence fragments in a single run. These fragments, or 'reads', can be used to measure levels of gene expression and to identify novel splice variants of genes. However, current sof...read more

Mentioned in this Paper

Gene Expression
RNA, Messenger, Splicing
Bio-Informatics
MRNA Differential Display
Determination, Sequence Homology
Poly(A) Tail
Fragments
RNA, Messenger
Computer Programs and Programming
Sequencing
11
1
5015
8
Paper Details
References
  • References17
  • Citations3812
12345...

TopHat: discovering splice junctions with RNA-Seq

Bioinformatics

May 1, 2009

Cole TrapnellSteven L. Salzberg

PMID: 19289445

DOI: 10.1093/bioinformatics/btp120

Abstract

A new protocol for sequencing the messenger RNA in a cell, known as RNA-Seq, generates millions of short sequence fragments in a single run. These fragments, or 'reads', can be used to measure levels of gene expression and to identify novel splice variants of genes. However, current sof...read more

Mentioned in this Paper

Gene Expression
RNA, Messenger, Splicing
Bio-Informatics
MRNA Differential Display
Determination, Sequence Homology
11
1
5015
8
Paper Details
References
  • References17
  • Citations3812
12345...

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