PMID: 10651372Jan 29, 2000

Topical 5-fluorouracil as primary therapy for keratoacanthoma

Annals of Plastic Surgery
R J Gray, N B Meland

Abstract

Keratoacanthoma is a common, benign cutaneous neoplasm that displays rapid growth on sun-exposed skin. Keratoacanthomas usually involute spontaneously after several months but rarely progress to squamous cell carcinoma. Because this is a benign, self-limited lesion of exposed skin, effective treatment should emphasize patient comfort and cosmetic results in addition to effectiveness. The authors present 2 patients with keratoacanthomas treated with topical 5-fluorouracil. Both patients had complete resolution of their lesions within 8 weeks. The cosmetic result was superb in both patients. Patient satisfaction with this therapy was excellent. Treatment can be instituted based on a clinical diagnosis; no diagnostic biopsy is necessary. Most keratoacanthomas respond to topical 5-fluorouracil therapy within 3 weeks, whereas squamous cell carcinomas respond poorly. Any lesion that shows a poor response after 3 weeks of therapy or that does not resolve within 8 weeks should undergo prompt excisional biopsy for definitive diagnosis and treatment. Topical 5-fluorouracil is an effective, convenient, relatively inexpensive treatment for keratoacanthoma that produces excellent cosmetic results. It should be added to the therapeutic armam...Continue Reading

Citations

Apr 18, 2003·Archives of Medical Research·Guillermo M Zúñiga-GonzálezApolinar López-Uribe
Jun 30, 2007·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Joseph F SobankoDavid A Kriegel
Sep 18, 2009·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Jason C HadleyMichael L Hadley
Oct 22, 2011·Clinics in Dermatology·Jennifer L DePryJerry D Brewer
Aug 17, 2012·The Journal of Investigative Dermatology·Amaya VirosRichard Marais
Sep 16, 2008·Annales de dermatologie et de vénéréologie·B Cribier
Apr 25, 2006·Journal of the American Academy of Dermatology·Sayuri YugeCleverson Teixeira Soares
Oct 12, 2002·Physics in Medicine and Biology·Feyzi Inanc
Jul 7, 2007·International Journal of Dermatology·Amel Karaa, Amor Khachemoune
Oct 9, 2019·Journal of Cutaneous Medicine and Surgery·Edward W SegerTing Wang
Dec 4, 2009·The Journal of Dermatological Treatment·Angela Yen Moore

Related Concepts

Administration, Topical
Antimetabolites
5-FU medac
Keratoacanthoma
Dermatologic Disorders
Client Satisfaction

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Carcinoma, Squamous Cell

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