Topical administration of iganidipine, a new water-soluble Ca2+ antagonist, increases ipsilateral optic nerve head circulation in rabbits and cynomolgus monkeys

Current Eye Research
Kiyoshi IshiiG Tomita

Abstract

To evaluate the effects of topically administered iganidipine hydrochloride, a novel water-soluble Ca2+- channel blocker, on optic nerve head (ONH) circulation in Dutch rabbits and cynomolgus monkeys. ONH tissue blood velocity (NBONH) was determined using the laser speckle method. In rabbits, NBONH was measured for 90 minutes before and after a single iganidipine administration, or before and after twice-daily ad- ministrations for 21 days (0.03%). In monkeys, NBONH was measured before and after twice-daily administrations of iganidipine for 7 days (0.03 or 0.1%). Iganidipine (0.03% solution) significantly increased NBONH by 8 to 10% in treated eyes after a single administration (p < 0.05) or by 18 to 35% after 7-, 14-, or 21-day twice-daily administration in rabbits (p < 0.05). In monkeys, 0.03% and 0.1% iganidipine significantly increased NBONH in treated eyes by 20 and 41% after 7-day (p < 0.05) twice-daily administration, respectively. Topical iganidipine significantly increased ONH blood velocity in treated eyes.

References

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Citations

Feb 5, 2008·American Journal of Veterinary Research·Andrew L GrellerAndrás M Komáromy
Oct 12, 2010·Progress in Retinal and Eye Research·Makoto Araie, Chihiro Mayama
Jan 17, 2013·Japanese Journal of Ophthalmology·Chihiro Mayama, Makoto Araie

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