Topical amiloride ointment accelerates healing of mechanical skin ulcers in albino rabbits and patients

Methods and Findings in Experimental and Clinical Pharmacology
Bhavyesh GuptaS K Bhargava

Abstract

The present investigation was undertaken to explore the ulcer-healing property of 1% amiloride ointment on mechanically produced skin ulcers in albino rabbits and at donor site of patients requiring split skin graft. Four skin ulcers measuring 2 X 2 cm(2) (two on either side of the midline) were made 2 cm apart on the pre-shaved back of each anesthetized rabbit up to the depth of subcutaneous tissue. Ulcers on one side of the midline were treated with sterile soft paraffin and served as control, whereas those on the other side were treated with amiloride ointment. Each ulcer was observed for its size, slough formation, and any sign of irritation on alternate days, until healing was complete. Healing of ulcers was significantly (p<0.001) accelerated with amiloride ointment in terms of days required for complete healing, ulcer size, and area under the size-time curve. In each patient, the anterior thigh was used as donor site. Grafts were harvested from midline using Watson's modification of Humby's knife. Each site was divided into proximal and distal halves and was covered with either soft paraffin tulle serving as control or 1% amiloride tulle as test site and then dressed conventionally. Healing was evaluated visually on 10th...Continue Reading

Citations

Jan 21, 2011·Journal of the American Academy of Dermatology·Zoe D DraelosNathan S Trookman
Dec 19, 2014·Scanning·Xiaoqin ZhuJianxin Chen
Apr 25, 2019·Skin Pharmacology and Physiology·Ewa Klara StuermerAnna-Lena Severing

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