Topical aminolaevulinic acid-photodynamic therapy for the treatment of acne vulgaris: a study of clinical efficacy and mechanism of action

The British Journal of Dermatology
B PollockW J Cunliffe

Abstract

Acne affects 83-95% of 16-year-olds of both sexes, and many seek help from a clinician. Emerging problems with conventional acne treatments, specifically antibiotic resistance of Propionibacterium acnes and fears over the safety and tolerance of oral isotretinoin, create a demand for novel treatment modalities in acne. To study the efficacy of aminolaevulinic acid-photodynamic therapy (ALA-PDT) in the treatment of acne and to identify the mode of action, looking specifically at the effects on surface numbers of P. acnes and on sebum excretion. Ten patients (nine men and one woman, age range 16-40 years) with mild to moderate acne on their backs were recruited. Each patient's back was marked with four 30-cm2 areas of equal acne severity. Each site was then randomly allocated to either ALA-PDT treatment, light alone, ALA alone or an untreated control site. At baseline, numbers of inflammatory and noninflammatory acne lesions were counted, sebum excretion measured by Sebutapes (CuDerm, Dallas, TX, U.S.A.) and surface P. acnes swabs performed. ALA cream (20% in Unguentum Merck) was applied under occlusion to the ALA-PDT and ALA alone sites for 3 h. Red light from a diode laser was then delivered to the ALA-PDT and light alone sites...Continue Reading

References

Dec 1, 1965·The Journal of Investigative Dermatology·P Williamson, A M Kligman
May 1, 1993·Journal of Photochemistry and Photobiology. B, Biology·K KönigR Steiner
Feb 27, 1993·BMJ : British Medical Journal·E A EadyA M Layton
Jan 1, 1997·Dermatology : International Journal for Clinical and Investigative Dermatology·V SigurdssonH van Weelden
Jun 22, 1999·Archives of Dermatology·C C DierickxR R Anderson
Aug 22, 2000·The Journal of Investigative Dermatology·W HongcharuR R Anderson
Sep 15, 2000·Archives of Dermatology·Y ItohA Ishibashi

❮ Previous
Next ❯

Citations

Jul 6, 2005·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·T MaischC Abels
Oct 4, 2005·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·C BorelliK Degitz
Jun 5, 2007·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·S Karrer, R-M Szeimies
Jan 29, 2010·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·C Borelli, H C Korting
Dec 1, 2005·Photodiagnosis and Photodynamic Therapy·Katie O'RiordanTayyaba Hasan
Jun 1, 2006·Photodiagnosis and Photodynamic Therapy·A Mitra, G I Stables
Mar 25, 2009·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Chi K YeungHenry H Chan
Mar 19, 2011·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Chi K YeungHenry H Chan
Jun 3, 2006·Photochemistry and Photobiology·Robert W Redmond, Irene E Kochevar
Jan 1, 2011·Laser Therapy·Yehuda UllmannLucian Fodor
Dec 21, 2012·Indian Journal of Dermatology, Venereology and Leprology·Cristian PintoAriel Hasson
Sep 1, 2007·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Amy Forman Taub
Jun 4, 2008·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Agustí TollRamon M Pujol
Feb 6, 2010·The Journal of Dermatological Treatment·Sejal K Shah, Andrew F Alexis
Nov 22, 2014·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Sophie Momen, Firas Al-Niaimi
Apr 4, 2015·Expert Review of Clinical Immunology·Aurélie ReinhardLaurent Peyrin-Biroulet
Jan 22, 2011·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Jee-Soo AnKee-Chan Moon
Jan 29, 2011·Expert Opinion on Pharmacotherapy·Claudine Piérard-FranchimontGérald E Piérard
Dec 5, 2014·Expert Opinion on Emerging Drugs·Imran AslamSteve Feldman
Oct 7, 2005·Drug Development and Industrial Pharmacy·Toshiyuki KosobeNorimichi Kawashima
Feb 22, 2016·Journal of the American Academy of Dermatology·Andrea L ZaengleinKevin M Boyer
Nov 26, 2013·Dermatologic Clinics·Sabrina Guillen Fabi, Andrei I Metelitsa
Mar 1, 2012·Photodiagnosis and Photodynamic Therapy·Sally Ibbotson
Nov 30, 2011·Seminars in Cutaneous Medicine and Surgery·Yoojin Lee, Elma D Baron
Nov 30, 2011·Photodiagnosis and Photodynamic Therapy·Hui-Lin DingZheng Huang
Oct 1, 2011·Journal of Photochemistry and Photobiology. B, Biology·Seung Yoon Celine LeeKi Ho Park
Mar 17, 2010·Photodiagnosis and Photodynamic Therapy·Xiu-Li WangZheng Huang
Jan 20, 2010·Clinics in Dermatology·Guy F Webster
May 20, 2008·Seminars in Cutaneous Medicine and Surgery·Mollie A MacCormack
Apr 25, 2015·Annales de dermatologie et de vénéréologie·C LavogiezS Mordon
Jun 1, 2007·Photodiagnosis and Photodynamic Therapy·Annelies BoiyPeter A M de Witte
Nov 28, 2006·Dermatologic Clinics·Mark S Nestor
May 13, 2005·Photodermatology, Photoimmunology & Photomedicine·Philipp BabilasRolf-Markus Szeimies
Oct 19, 2005·Dermatologic Therapy·E Victor Ross
Feb 26, 2009·The British Journal of Dermatology·F L HamiltonA Majeed
Feb 26, 2009·The British Journal of Dermatology·M N Taylor, M L Gonzalez
Sep 30, 2009·The Journal of Dermatology·Akiko OhtsukiShigaku Ikeda
Feb 21, 2008·The British Journal of Dermatology·S R WiegellH C Wulf
Jan 29, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·M HaedersdalH C Wulf
Apr 15, 2006·Photochemistry and Photobiology·Sachiko KosakaBernhard Ortel
Sep 7, 2007·Photodermatology, Photoimmunology & Photomedicine·R AkaraphanthP Gritiyarangsan
Oct 24, 2008·The British Journal of Dermatology·C A MortonUNKNOWN British Association of Dermatologists Therapy Guidelines and Audit Subcommittee and the British Photodermatology Group

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.